持续皮下胰岛素注射治疗老年2型糖尿病疾病的价值分析  

Clinical Value of Continuous Subcutaneous Insulin Injection in Elderly Pa⁃tients with Type 2 Diabetes Mellitus

作　　者：冯珺茹 韩文鹏 FENG Junru;HAN Wenpeng(Department of Internal Medicine,Tengzhou Second People's Hospital,Tengzhou 277599,Shandong,China)

机构地区：[1]滕州市第二人民医院内科,山东滕州277599

出　　处：《糖尿病新世界》2024年第11期4-7,共4页Diabetes New World

摘　　要：目的分析老年2型糖尿病运用持续皮下胰岛素注射治疗的效果。方法选取2023年2月—2024年2月滕州市第二人民医院内科收治的78例老年2型糖尿病患者为研究对象,以治疗方法的不同分为对照组(39例,接受生物合成人胰岛素多次皮下注射)、观察组(39例,接受持续皮下胰岛素注射),比较两组血糖变化情况(血糖日平均绝对差、血糖日平均波动速度)、血糖情况(空腹血糖、餐后2 h血糖)、胰岛细胞功能(胰岛素抵抗指数、胰岛β细胞功能指数)、氧化应激指标(超氧化物歧化酶、丙二醛)。结果观察组血糖日平均绝对差、血糖日平均波动速度均小于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组血糖(空腹血糖、餐后2 h血糖)水平均低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组胰岛素抵抗指数低于对照组,胰岛β细胞功能指数高于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组治疗后丙二醛低于对照组,超氧化物歧化酶高于对照组,差异有统计学意义(P均<0.05)。结论老年2型糖尿病运用持续皮下胰岛素注射治疗的效果更好,有利于调节胰岛功能,并且在短时间内快速控制血糖指标。Objective To investigate the effect of continuous subcutaneous injection of insulin in elderly patients of type 2 diabetes mellitus.Methods A total of 78 elderly patients with type 2 diabetes mellitus admitted to the Depart-ment of Internal Medicine of Tengzhou Second People's Hospital from February 2023 to February 2024 were selected as the research objects.They were divided into control group(39 cases,received multiple subcutaneous injections of biosynthetic human insulin)and observation group(39 cases,received continuous subcutaneous insulin injection)by different treatment methods.The changes of blood glucose(average daily absolute difference of blood glucose and the average daily fluctuation rate of blood glucose),blood glucose(fasting blood glucose,2-hour postprandial blood glu-cose),islet cell function(insulin resistance index,isletβcell function index),oxidative stress index(superoxide dismutase,malondialdehyde)were compared between the two groups.Results The average daily absolute difference of blood glucose and the average daily fluctuation rate of blood glucose in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).After treatment,the blood glucose level(fasting blood glucose,2-hour postprandial blood glucose)of the observation group were lower than those of the control group,and the differences were statistically significant(both P<0.05).After treatment,the insulin resistance in-dex of the observation group was lower than that of the control group,and the isletβcell function index was higher than that of the control group,the differences were statistically significant(both P<0.05).After treatment,the malondi-aldehyde in the observation group was lower than that in the control group,and the superoxide dismutase was higher than that in the control group,the differences were statistically significant(both P<0.05).Conclusion The effect of continuous subcutaneous insulin injection in elderly patients with type 2 diabetes mellitu

关 键 词：老年 2型糖尿病 持续皮下注射胰岛素 血糖波动 胰岛功能 

分 类 号：R4[医药卫生—临床医学]