尿微量白蛋白、N-乙酰-β-D-葡萄糖苷酶及血清胱抑素C联合检测在糖尿病早期肾损伤诊断中的价值分析  

Value of Combined Detection of Microalbuminuria,N-acetyl-β-D-glucosidase and Serum CystatinC in the Diagnosis of Early Kidney Damage in Diabetes Mellitus

作　　者：张婕 陈玉凤 王清华[1] ZHANG Jie;CHEN Yufeng;WANG Qinghua(Department of Clinical Laboratory,Rizhao People's Hospital,Rizhao 276826,Shandong,China)

机构地区：[1]日照市人民医院检验科,山东日照276826

出　　处：《糖尿病新世界》2024年第11期38-40,44,共4页Diabetes New World

摘　　要：目的分析尿微量白蛋白(microalbuminuria,m-ALB)、N-乙酰-β-D-葡萄糖苷酶(N-acetyl-β-D-glucosidase,NAG)及血清胱抑素C(cystatin C,CysC)联合检测在糖尿病早期肾损伤(early kidney damage in dia⁃betes,EKDID)诊断中的价值。方法回顾性选取2021年6月—2022年12月日照市人民医院收治的60例EKDID患者(A组)、60例单纯糖尿病患者(B组)和30名健康体检人群(C组)的临床资料,均进行尿m-ALB、NAG及血清CysC检查,比较3组尿m-ALB、NAG及血清CysC水平,并分析各项指标单独及联合检测的灵敏度、特异度、准确度、阳性预测值、阴性预测值。结果A组尿m-ALB、NAG及血清CysC水平均高于B组、C组,差异有统计学意义(P均<0.05);B组、C组间各指标水平比较,差异无统计学意义(P均>0.05)。三项指标联合检测EKDID的灵敏度、阴性预测值均高于各单项及两两组合检测,差异有统计学意义(P均<0.05)。结论尿m-ALB、NAG及血清Cys三项指标联合检测可明显提高诊断EKDID的价值。Objective To analyze the value of combined detection of microalbuminuria(m-ALB),N-acetyl-β-D-glucosidase(NAG)and serum cystatin C(CysC)in the diagnosis of early kidney damage in diabetes(EKDID).Methods The clinical data of 60 patients with EKDID(group A),60 patients with simple diabetes(group B)and 30 healthy subjects(group C)admitted to Rizhao People's Hospital from June 2021 to December 2022 were retrospec-tively selected.Urinary m-ALB,NAG and serum CysC were examined.The levels of urinary m-ALB,NAG and serum CysC in the three groups were compared,and the sensitivity,specificity,accuracy,positive predictive value and nega-tive predictive value of each index alone and combined detection were analyzed.Results Urinary m-ALB,NAG and serum CysC levels in group A were higher than those in groups B and C,and the differences were statistically signifi-cant(all P<0.05).There were no statistically significant differences between group B and group C in the three indica-tors level(all P>0.05).The sensitivity and negative predictive value of the combined detection of the three indexes were higher than those of the single and pin-two detection,and the differences were statistically significant(all P<0.05).Conclusion The combined detection of urinary m-ALB,NAG and serum CysC significantly improved the diag-nostic value of EKDID.

关 键 词：糖尿病早期肾损害 尿微量白蛋白、N-乙酰-β-D-葡萄糖苷酶 血清胱抑素C 联合检测 

分 类 号：R446.1[医药卫生—诊断学]