血清FPG、2 hPG和HbA1c在妊娠期糖尿病孕妇中的诊断价值分析  

Diagnostic Value of Serum FPG,2 hPG,and HbA1c in Pregnant Women with Gestational Diabetes Mellitus

作　　者：何欣 杨金荣 HE Xin;YANG Jinrong(Department of Laboratory,Jianning County Maternal and Child Health Hospital,Sanming 354500,Fujian,China;Department of Laboratory,Jianning County General Hospital,Sanming 354500,Fujian,China)

机构地区：[1]福建省三明市建宁县妇幼保健院检验科,福建三明354500 [2]福建省三明市建宁县总院检验科,福建三明354500

出　　处：《糖尿病新世界》2024年第11期45-47,55,共4页Diabetes New World

摘　　要：目的分析空腹血糖(fasting plasma glucose,FPG)、餐后2 h血糖(2-hour postprandial plasma glucose,2 hPG)、糖化血红蛋白(glycated hemoglobin A1c,HbA1c)在妊娠期糖尿病(gestational diabetes mellitus,GDM)孕妇中的诊断价值。方法选取2021年11月—2023年11月福建省三明市建宁县妇幼保健院收治的200例GDM孕妇纳入观察组,另将同期于本院行产前检查的198名健康孕妇纳入对照组。比较两组FPG、2 hPG、HbA1c水平,并描绘受试者操作特征(receiver operating characteristic,ROC)曲线,探究FPG、2 hPG、HbA1c诊断GDM的价值。结果观察组FPG、2 hPG、HbA1c水平均高于对照组,差异有统计学意义(P均<0.05)。ROC曲线分析结果显示,FPG、2 hPG、HbA1c联合诊断GDM的曲线下面积为0.957,高于三者单独诊断,差异有统计学意义(P<0.05)。结论FPG、2 hPG、HbA1c在GDM孕妇体内呈异常高表达,3项指标联合可有效诊断出GDM。Objective To analyze the diagnostic value of fasting plasma glucose(FPG),2-hour postprandial plasma glucose(2hPG),and glycated hemoglobin A1c(HbA1c)in pregnant women with gestational diabetes mellitus(GDM).Methods From November 2021 to November 2023,200 pregnant women with GDM admitted to Jianning County Ma-ternal and Child Health Hospital of Sanming in Fujian Province were selected as the observation group,and 198 healthy pregnant women who underwent prenatal examination in our hospital during the same period were included in the control group.The levels of FPG,2 hPG and HbA1c were compared between the two groups,and the receiver oper-ating characteristic(ROC)curve was drawn to explore the value of FPG,2 hPG and HbA1c in the diagnosis of GDM.Results The levels of FPG,2 hPG and HbA1c in the observation group were higher than those in the control group,and the differences were statistically significant(all P<0.05).ROC curve analysis results showed that the area under the curve of FPG,2 hPG and HbA1c in the diagnosis of GDM was 0.957,which was higher than that of the three alone,and the difference was statistically significant(P<0.05).Conclusion FPG,2 hPG and HbA1c were abnormally highly expressed in GDM pregnant women,and the combination of the three indicators could effectively diagnose GDM.

关 键 词：妊娠期糖尿病 空腹血糖 餐后2 h血糖 糖化血红蛋白 

分 类 号：R587.1[医药卫生—内分泌]