胱抑素C、β2微球蛋白、同型半胱氨酸在糖尿病肾病中的应用价值分析  

Analysis of the Application Value of Cystatin C,β2-microglobulin and Ho⁃mocysteine in Diabetic Nephropathy

作　　者：杨姣婧 刘义迁 孔春香 YANG Jiaojing;LIU Yiqian;KONG Chunxiang(Department of Clinical Laboratory,Rudong County Hospital of Traditional Chinese Medicine,Nantong 226400,Jiangsu,China;Department of Clinical Laboratory,Nantong Zilang Hospital,Nantong 226000,Jiangsu,China;Department of Clinical Laboratory,the Fourth People's Hospital of Rudong County,Nantong 226400,Jiangsu,China)

机构地区：[1]如东县中医院检验科,江苏南通226400 [2]南通市紫琅医院检验科,江苏南通226000 [3]如东县第四人民医院检验科,江苏南通226400

出　　处：《糖尿病新世界》2024年第11期48-51,共4页Diabetes New World

摘　　要：目的探究对糖尿病肾病患者采用胱抑素C(cystatin C,Cys-C)、β2微球蛋白(β2-microglobulin,β2-MG)、同型半胱氨酸(homocysteine,Hcy)检测的应用价值。方法选取2020年1月—2023年7月如东县中医院收治的63例糖尿病肾病患者为A组,选择同期32例糖尿病无肾病患者为B组,以及选择31名健康体检者为C组。三组均进行Cys-C、β2-MG、Hcy检测,比较三组指标水平,同时采用受试者操作特征(receiver operating characteristic,ROC)曲线,基于曲线下面积(area under curve,AUC)探究指标的诊断价值。结果A组Cys-C、β2-MG、Hcy水平均高于B组、C组,差异有统计学意义(P均<0.05)。ROC曲线分析结果显示Cys-C、β2-MG、Hcy联合检测的AUC为0.942,高于其他单一指标,差异有统计学意义(P<0.05)。结论Cys-C、β2-MG、Hcy联合检测对糖尿病肾病疾病有着较高的诊断价值,可为临床后续治疗提供可靠的依据。Objective To investigate the application value of cystatin C(Cys-C),β2-microglobulin(β2-MG)and ho⁃mocysteine(Hcy)detection in patients with diabetic nephropathy.Methods A total of 63 patients with diabetic ne⁃phropathy admitted to Rudong County Hospital of Traditional Chinese Medicine from January 2020 to July 2023 were selected as group A,32 patients with diabetes without nephropathy in the same period were selected as group B,and 31 healthy subjects were selected as group C.The levels of Cys-C,β2-MG and Hcy were detected in the three groups,and the levels of the three groups were compared.The receiver operating characteristic(ROC)curve was used to explore the diagnostic value of the indicators based on the area under the curve(AUC).Results The levels of Cys-C,β2-MG and Hcy in group A were higher than those in group B and group C,and the differences were statistically significant(all P<0.05).The results of ROC curve analysis showed that the AUC of combined detection of Cys-C,β2-MG and Hcy was 0.942,which was higher than that of other single indicators,and the difference was statistically sig⁃nificant(P<0.05).Conclusion Combined detection of Cys-C,β2-MG,Hcy level has high diagnostic value for dia⁃betic nephropathy disease,which can provide a reliable basis for the clinical follow-up treatment.

关 键 词：胱抑素 Β2微球蛋白 同型半胱氨酸 糖尿病肾病 诊断价值 

分 类 号：R587[医药卫生—内分泌]