门冬胰岛素在妊娠期糖尿病治疗中的应用  

Application of Insulin Aspart in the Treatment of Gestational Diabetes

作　　者：王烈霞 WANG Liexia(Department of Obstetrics,the Second People's Hospital of Xining,Xining 810000,Qinghai,China)

机构地区：[1]青海省西宁市第二人民医院产科,青海西宁810000

出　　处：《糖尿病新世界》2024年第11期63-66,共4页Diabetes New World

摘　　要：目的以提高妊娠期糖尿病治疗水平为研究目标,在临床中实施门冬胰岛素方案,明确其对妊娠期糖尿病患者的影响。方法选取2023年1—12月青海省西宁市第二人民医院收治的65例妊娠期糖尿病患者为研究对象,按治疗方法不同分为对照组(34例)、观察组(31例),对照组应用常规方案,观察组应用门冬胰岛素方案。比较两组药物不良反应、糖脂代谢指标(空腹血糖指标、餐后2 h血糖指标、糖化血红蛋白、总胆固醇、低密度脂蛋白胆固醇)、胰岛功能指标(空腹胰岛素指标、胰岛素抵抗指数)、血糖达标时间、日胰岛素总量、母婴不良结局。结果干预后,观察组药物不良反应、糖脂代谢指标、胰岛功能指标、血糖达标时间、日胰岛素总量、母婴不良结局等均低于对照组,差异有统计学意义(P均<0.05)。结论在临床中实施门冬胰岛素方案,有利于改善妊娠期糖尿病患者各项指标,提高生活质量。Objective To improve the treatment level of gestational diabetes,to implement insulin aspart program in clinical practice,and to clarify its impact on patients with gestational diabetes.Methods A total of 65 patients with gestational diabetes mellitus admitted to the Second People's Hospital of Xining,Qinghai Province from January to December 2023 were selected as the research objects.According to different treatment methods,they were divided into control group(34 cases)and observation group(31 cases).The control group was treated with conventional regimen,and the observation group was treated with insulin aspart regimen.The adverse drug reactions,glucose and lipid me⁃tabolism indexes(fasting blood glucose index,postprandial 2-hour blood glucose index,glycosylated hemoglobin,total cholesterol,low density lipoprotein cholesterol),islet function indexes(fasting insulin index,insulin resistance index),blood glucose compliance time,total daily insulin,maternal and infant adverse outcomes were compared between the two groups.Results After intervention,the adverse drug reactions,glucose and lipid metabolism indexes,islet func⁃tion indexes,blood glucose compliance time,total daily insulin,and maternal and infant adverse outcomes in the ob⁃servation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion The implementation of aspart insulin program in clinical practice is beneficial to inprove the various indicators of diabetes patients during pregnancy and their quality of life.

关 键 词：妊娠期糖尿病 门冬胰岛素 糖脂代谢 

分 类 号：R587.1[医药卫生—内分泌]