降糖宁胶囊联合二甲双胍治疗妊娠期糖尿病的临床疗效及安全性分析  

Clinical Efficacy and Safety of Jiangtangning Capsule Combined with Metformin in the Treatment of Gestational Diabetes Mellitus

作　　者：潘东梅 杨艺红 谢聪 PAN Dongmei;YANG Yihong;XIE Cong(Army 73rd Group Hospital of the Chinese People's Liberation Army,Xiamen 361000,Fujian,China)

机构地区：[1]中国人民解放军陆军第七十三集团军医院,福建厦门361000

出　　处：《糖尿病新世界》2024年第11期108-110,117,共4页Diabetes New World

摘　　要：目的分析降糖宁胶囊联合二甲双胍治疗妊娠期糖尿病的疗效。方法回顾性选取2023年2月—2024年3月中国人民解放军陆军第七十三集团军医院收治的122例妊娠期糖尿病患者的临床资料,根据治疗方法不同分为两组,每组61例。对照组采用二甲双胍治疗,研究组采用二甲双胍联合降糖宁胶囊治疗,治疗时间为1个月。对比两组糖脂代谢水平(糖化血红蛋白、空腹血糖,总胆固醇、甘油三酯)、不良妊娠结局(早产儿、胎儿宫内窘迫、巨大儿、新生儿窒息)、不良反应(头晕恶心、乏力、低血糖、腹胀腹泻)发生率、临床疗效。结果治疗前,两组糖脂代谢水平比较,差异无统计学意义(P均>0.05);治疗后,两组糖脂代谢水平均有改善,且研究组糖脂代谢水平优于对照组,差异有统计学意义(P均<0.05)。研究组不良妊娠结局发生率为1.64%(1/61),低于对照组的13.11%(8/61),差异有统计学意义(χ^(2)=4.319,P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论降糖宁胶囊联合二甲双胍治疗妊娠期糖尿病能够显著改善糖脂代谢水平、降低不良妊娠结局及不良反应发生风险,还可提高临床疗效。Objective To analyze the efficacy of Jiangtangning Capsules combined with metformin in treatment of ges-tational diabetes mellitus.Methods The clinical data of 122 patients with gestational diabetes mellitus admitted to Ammy 73rd Group Hospital of the Chinese People's Liberation Army from February 2023 to March 2024 were retro-spectively selected.According to different treatment methods,they were divided into two groups,with 61 cases in each group.The control group was treated with metformin,and the study group was treated with metformin combined with Jiangtangning Capsule.The treatment time was 1 month.The levels of glucose and lipid metabolism(glycated hemoglo-bin A1c,fasting plasma glucose,total cholesterol,triglyceride),adverse pregnancy outcomes(premature infants,fetal distress,macrosomia,neonatal asphyxia),adverse reactions(dizziness and nausea,fatigue,hypoglycemia,abdominal distension and diarrhea)and clinical efficacy were compared between the two groups.Results Before the treatment,the leves of glucolipid metabolism of two groups were compared,and the differences were not statistically significant(all P>0.05).After treatment,the leves of glucolipid metabolism of two groups were improved,and the study group was better than that of control group,the differences were statistically significant(all P<0.05).The incidence of adverse pregnancy outcome of study group was 1.64%(1/61);which was lower than control group of 13.11%(8/61),the differ-ence was statistically significant(χ^(2)=4.319,P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Jiangtangning Capsule com-bined with metformin in the treatment of gestational diabetes mellitus can significantly improve the level of glucose and lipid metabolism,reduce the risk of adverse pregnancy outcomes and adverse reactions,and improve the cl

关 键 词：降糖宁胶囊 二甲双胍 妊娠期糖尿病 糖脂代谢 不良反应发生率 

分 类 号：R587.1[医药卫生—内分泌]