小剂量胰岛素联合生长抑素治疗糖尿病酮症酸中毒合并急性胰腺炎效果及不良反应分析  

Efficacy and Adverse Reactions of Low-dose Insulin Combined with Somatostatin in the Treatment of Diabetes Ketoacidosis with Acute Pancreatitis

作　　者：马广跃 李季 赵海滨 MA Guangyue;LI Ji;ZHAO Haibin(Department of Intensive Care Medicine,Yicheng District People's Hospital,Zaozhuang 277300,Shandong,China;Department of Endocrinology,Yicheng District People's Hospital,Zaozhuang 277300,Shandong,China;Department of General Surgery,Yicheng District People's Hospital,Zaozhuang 277300,Shandong,China)

机构地区：[1]枣庄市峄城区人民医院重症医学科,山东枣庄277300 [2]枣庄市峄城区人民医院内分泌科,山东枣庄277300 [3]枣庄市峄城区人民医院普外科,山东枣庄277300

出　　处：《糖尿病新世界》2024年第11期183-186,共4页Diabetes New World

摘　　要：目的探究小剂量胰岛素联合生长抑素在糖尿病酮症酸中毒合并急性胰腺炎中的应用效果。方法选取枣庄市峄城区人民医院于2020年5月—2022年5月接受治疗的58例糖尿病酮症酸中毒(diabetic ketoaci⁃dosis,DKA)合并急性胰腺炎(acute pancreatitis,AP)患者为研究对象,根据不同治疗方案分为研究组(n=29)与对照组(n=29),其中对照组接受常规方案治疗,研究组采用小剂量胰岛素联合生长抑素治疗,比较两组临床指标(血糖、甘油三酯、血液淀粉酶、血酮体)、症状改善情况(腹痛、酸中毒、血糖改善时间)、不良反应发生情况(呕吐加重、排便困难、头晕)。结果治疗前,两组血糖、甘油三酯、血液淀粉酶、血酮体等指标比较,差异无统计学意义(P均>0.05);治疗后,两组各临床指标均低于治疗前,且研究组均低于对照组,差异有统计学意义(P均<0.05)。研究组血糖恢复时间、酸中毒纠正时间、腹痛改善时间均短于对照组,差异有统计学意义(P均<0.05)。研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论小剂量胰岛素联合生长抑素方案在治疗DKA合并AP中具有确切疗效,同时不良反应少,值得临床应用。Objective To explore the application effect of low-dose insulin combined with somatostatin in diabetic ke-toacidosis complicated with acute pancreatitis.Methods A total of 58 patients with diabetic ketoacidosis(DKA)com-plicated with acute pancreatitis(AP)who were treated in Yicheng District People's Hospital of Zaozhuang from May 2020 to May 2022 were selected as the research objects.They were divided into study group(n=29)and control group(n=29)according to different treatment regimens.The control group received conventional treatment,and the study group was treated with low-dose insulin combined with somatostatin.Clinical indicators(blood glucose,triglyceride,blood amylase,blood ketone body),symptom improvement(abdominal pain,acidosis,blood glucose improvement time),adverse reactions(vomiting,difficulty defecating,dizziness)were compared between the two groups.Results Be-fore treatment,there was no significant difference in blood glucose,triglyceride,blood amylase and blood ketone be-tween the two groups(all P>0.05).After treatment,the clinical indexes of the two groups were lower than those before treatment,and the study group were lower than the control group,and the differences were statistically significant(all P<0.05).The blood glucose recovery time,acidosis correction time and abdominal pain improvement time in the study group were shorter than those in the control group,and the differences were statistically significant(all P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group,and the difference was sta-tistically significant(P<0.05).Conclusion Low-dose insulin combined with somatostatin regimen is effective in the treatment of DKA combined with AP,and has fewer adverse reactions,which is worthy of clinical application.

关 键 词：糖尿病酮症酸中毒 小剂量胰岛素 急性胰腺炎 生长抑素 

分 类 号：R587[医药卫生—内分泌]