不同严重程度糖尿病肾病与UAE、血清β2-MG、CysC、UACR的相关性研究  

Study on the Correlation Between Diabetic Nephropathy of Different Se⁃verity and UAE,Serumβ2-MG,CysC,and UACR

作　　者：魏兰春 WEI Lanchun(Department of Clinical Laboratory,Mingxi General Hospital,Sanming 365200,Fujian,China)

机构地区：[1]福建省三明市明溪县总医院检验科,福建三明365200

出　　处：《糖尿病新世界》2024年第11期187-189,194,共4页Diabetes New World

摘　　要：目的探究不同病情严重程度糖尿病肾病与尿白蛋白排泄率(urinary albumine xcretion,UAE)、血清β2微球蛋白(β2-microglobulin,β2-MG)、胱抑素C(cystatin C,CysC)、尿微量白蛋白与尿肌酐比值(albumin/cre⁃atinine ratio,UACR)的相关性。方法选取2020年11月—2023年12月福建省三明市明溪县总医院收治的174例2型糖尿病肾病患者作为研究对象,依据糖尿病肾病分期分为Ⅰ期组(n=40)、Ⅱ期组(n=37)、Ⅲ期组(n=32)、Ⅳ期组(n=35)、Ⅴ期组(n=30)。选择同期在本院体检的60例健康人作为对照组。比较以上所有组的血清β2-MG、CysC、UACR、UAE水平,并对不同病情严重程度与UAE、血清β2-MG、CysC、UACR进行相关性分析。结果Ⅰ期组、Ⅱ期组、Ⅲ期组、Ⅳ期组、Ⅴ期组与对照组血清β2-MG、CysC、UACR、UAE水平比较,差异有统计学意义(P均<0.05);Ⅰ期组与Ⅱ期组、Ⅲ期组、Ⅳ期组、Ⅴ期组血清β2-MG、CysC、UACR、UAE水平相比,差异有统计学意义(P均<0.05);Ⅱ期组与Ⅲ期组、Ⅳ期组、Ⅴ期组血清β2-MG、CysC、UACR、UAE水平相比,差异有统计学意义(P均<0.05)。Pearson相关性分析结果显示,UAE、血清β2-MG、CysC、UACR水平与糖尿病肾病病情严重程度呈正相关(P均<0.05)。结论不同病情严重程度糖尿病肾病患者的UAE、血清β2-MG、CysC、UACR具有相关性,疾病越严重,UAE、血清β2-MG、CysC、UACR水平就越高。Objective To explore the correlation between different severity of diabetic nephropathy and urinary albu-min excretion rate(UAE),serumβ2-microglobulin(β2-MG),cystatin C(CysC),urinary albumin/creatinine ratio(UACR).Methods A total of 174 patients with type 2 diabetic nephropathy admitted to Mingxi General Hospital of Sanming in Fujian Province from November 2020 to December 2023 were selected as the research objects.According to the stage of diabetic nephropathy,the patients were divided into stage I group(n=40),stageⅡgroup(n=37),stageⅢgroup(n=32),stageⅣgroup(n=35)and stage V group(n=30).Sixty healthy people who underwent physical exami-nation in our hospital during the same period were selected as the control group.The levels of serumβ2-MG,CysC,UACR and UAE in all groups were compared,and the correlation between the severity of different diseases and UAE,serum serumβ2-MG,CysC and UACR was analyzed.Results There were statistically significant differences in the levels ofβ2-MG,CysC,UACR and UAE between stage I group,stageⅡgroup,stageⅢgroup,stageⅣgroup,stage V group and control group(all P<0.05).The levels of serumβ2-MG,CysC,UACR and UAE in stage I group were sta-tistically differences from those in stageⅡgroup,stageⅢgroup,stageⅣgroup and stage V group(all P<0.05).There were statistically significant differences in the levels of serumβ2-MG,CysC,UACR and UAE between stageⅡgroup and stageⅢgroup,stageⅣgroup and stage V group(all P<0.05).Pearson correlation analysis showed that UAE,serumβ2-MG,CysC and UACR levels were positively correlated with the severity of diabetic nephrapathy(all P<0.05).Conclusion There was a correlation between UAE,serumβ2-MG,CysC and UACR in patients with different severity of diabetic nephropathy.The more severe the disease,the higher the levels of UAE,serumβ2-MG,CysC and UACR.

关 键 词：糖尿病肾病 尿蛋白 β2微球蛋白 胱抑素 尿微量白蛋白 尿肌酐 

分 类 号：R446.1[医药卫生—诊断学]