Toward innovative veterinary nanoparticle vaccines  

作　　者：Meiqi Sun Aldryan Cristianto Pratama He Qiu Zehui Liu Fang He 

机构地区：[1]Institute of Preventive Veterinary Medicine,College of Animal Sciences of Zhejiang University,866 Yuhangtang Road,Hangzhou 310058,China [2]Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine,Hangzhou 310058,China [3]ZJU-Xinchang Joint Innovation Centre(TianMu Laboratory),Gaochuang Hi‑Tech Park,Xinchang 312500,Zhejiang,China [4]Department of Cardiology,Cardiovascular Key Lab of Zhejiang Province,The Second Affiliated Hospital,Zhejiang University School of Medicine,Zhejiang University,Hangzhou,China

出　　处：《Animal Diseases》2024年第2期78-97,共20页动物疾病（英文）

摘　　要：Nanoparticles are significant for veterinary vaccine development because they are safer and more effective than conventional formulations.One promising area of research involves self-assembled protein nanoparticles(SAPNs),which have shown potential for enhancing antigen-presenting cell uptake,B-cell activation,and lymph node trafficking.Numerous nanovaccines have been utilized in veterinary medicine,including natural self-assembled protein nanoparticles,rationally designed self-assembled protein nanoparticles,animal virus-derived nanoparticles,bacteriophagederived nanoparticles,and plant-derived nanoparticles,which will be discussed in this review.SAPN vaccines can produce robust cellular and humoral immune responses and have been shown to protect against various animal infectious diseases.This article attempts to summarize these diverse nanovaccine types and their recent research progress in the field of veterinary medicine.Furthermore,this paper highlights their disadvantages and methods for improving their immunogenicity.

关 键 词：NANOPARTICLES Veterinary vaccine Self-assembling protein nanoparticles(SAPNs) Virus-like nanoparticles(VLPs) Immune responses Animal infectious diseases Optimization strategies 

分 类 号：S85[农业科学—兽医学]