Chronic social defeat stress‑induced depression reduces BCG efficacy by promoting regulatory T‑cell levels in mice  

作　　者：Rohit Tyagi Xi Chen Atika Dhar Bing Yang Wei Zhou Aikebaier Reheman Yingying Lei Gang Cao 

机构地区：[1]National Key Laboratory of Agricultural Microbiology,College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,China [2]National Institute of Immunology,New Delhi 110067,India [3]College of Animal Science and Technology,Tarim University,Alar 843300,China [4]Bio‑Medical Center,Huazhong Agricultural University,Wuhan 430070,China

出　　处：《Animal Diseases》2024年第2期115-126,共12页动物疾病（英文）

基　　金：funded by the National Natural Science Foundation of China(Grant No.U21A20259,31602061,31872470);the National Key Research and Development Program of China(Grant No.2021YFD1800401).

摘　　要：Despite the initial successes of the Bacillus Calmette-Guerin(BCG)vaccine in children,its efficacy against tuberculosis is highly variable.There is a lack of understanding about how mental conditions influence BCG vaccination.Here,we used the chronic social defeat stress(CSDS)model to explore the effects of depression on BCG vaccination efficacy.We observed higher lung and spleen bacterial loads and a lower organ index in depressed compared to BCG mice.Meanwhile,a relatively lower T cell protective efficacy was observed in both compared to control and BCG mice via a mycobacterium growth inhibition assay(MGIA).Cytokine expression of IL-12p40,IL-1β,IL-17,TNF-αand IFN-γwas reduced,whereas the expression of IL-10 and IL-5 was increased in the spleen of both compared to BCG mice.Moreover,the proportions of CD4^(+)IFN-γ^(+),CD8^(+)IFN-γ^(+)T lymphocytes and CD4^(+)effector/central memory T cells were reduced in the splenocytes of the depressed BCG mice.Depression promotes CD4^(+)regulatory T cells(Treg)and myeloid-derived suppressor cell(MDSC)generation in depressed mice,contributing to the reduced pro-inflammatory immune response upon BCG vaccination.This study provides insight into the decreased protective immunity by BCG vaccination attributable to depression in mice.

关 键 词：BCG Vaccine efficacy TREG Immune suppression DEPRESSION 

分 类 号：R186[医药卫生—流行病学]