利奈唑胺相关血液及代谢系统不良反应研究进展  

Advances in the study of linezolid-related adverse reactions of blood and metabolic system

作　　者：苟军强 李倩 尹东锋[2] 王晓锋 Gou Jun-Qiang;Li Qian;Yin Dong-Feng;Wang Xiao-Feng(College of Pharmacy,Shihezi University,Shihezi,Xinjiang 832003,China;Department of Pharmacy,Xinjiang Military Command General Hospital,Urumqi,Xinjiang 830000,China)

机构地区：[1]石河子大学药学院,新疆石河子832003 [2]新疆军区总医院药剂科,新疆乌鲁木齐830000

出　　处：《解放军医学杂志》2024年第8期965-972,共8页Medical Journal of Chinese People's Liberation Army

摘　　要：利奈唑胺是全合成的唑烷酮类抗菌药物,主要用于治疗由革兰阳性耐药菌引起的重症感染。近年来,随着耐药菌的增多,利奈唑胺临床使用率及其相关的血液及代谢系统不良反应发生率也增高,其相关不良反应主要有血小板减少、贫血和乳酸酸中毒等。研究显示利奈唑胺引起血液系统及代谢系统不良反应的诱因多样且发生机制尚未完全阐明。本文结合近期国内外文献报道,探讨利奈唑胺的体内药代动力学特点、不良反应发生机制与危险因素,以及预防措施和个体化给药策略等,以期为利奈唑胺相关血液及代谢系统不良反应的临床防治提供参考。Linezolid,a fully synthetic oxazolidinone antibiotic,is mainly used to treat severe infections caused by Gram-positive drug-resistant bacteria.In recent years,with the rise in drug-resistant bacteria,the clinical utilization rate of linezolid and the incidence of linezolid-related adverse reactions in the hematological system and metabolic system have increased.The main adverse reactions include thrombocytopenia,anemia and lactic acidosis.Studies have shown that the causes of adverse reactions in linezolid-induced hematological system and metabolic system are diverse,and the mechanisms are not fully elucidated.In this review,the pharmacokinetic characteristics,mechanism of adverse reactions,risk factors,as well as preventive measures and individualized drug administration strategies of linezolid in vivo were discussed based on literature reports at home and abroad,aiming to provide references for clinical prevention and treatment of linezolid-related adverse reactions of hematological system and metabolic system.

关 键 词：利奈唑胺 血液 代谢 不良反应 个体化给药 

分 类 号：R978.1[医药卫生—药品] R521[医药卫生—药学]