腰椎退行性病变患者黄韧带BMP-2、VEGF和维生素D受体水平变化分析  

Changes of BMP-2,VEGF and vitamin D receptor levels in ligamenta flavum in patients with lumbar degenerative diseases

作　　者：王凤涛 阮艳玲 孙如莹 韩静 杜谢琴 WANG Feng-tao;RUAN Yan-ling;SUN Ru-ying;HAN Jing;DU Xie-qin(Wuhan Third Hospital Orthopedics,Wuhan,Hubei 432000,China;Wuhan Third Hospital Major Surgery,Wuhan,Hubei 432000,China;Wuhan Third Hospital General Surgery,Wuhan,Hubei 432000,China)

机构地区：[1]武汉市第三医院骨外科,湖北武汉432000 [2]武汉市第三医院大外科,湖北武汉432000 [3]武汉市第三医院普外科,湖北武汉432000

出　　处：《颈腰痛杂志》2024年第4期643-646,共4页The Journal of Cervicodynia and Lumbodynia

摘　　要：目的探讨腰椎退行性病变[腰椎间盘突出症(LDH)和腰椎管狭窄症(LSS)]患者黄韧带骨形态发生蛋白(BMP)-2、血管内皮生长因子(VEGF)和维生素D受体(VDR)水平变化。方法选择2019年1月至2021年12月在该院接受手术治疗的LSS患者作为LSS组(n=43),LDH患者作为LDH组(n=47),选择同期在该院行手术治疗的腰椎骨折患者作为对照组(n=33)。观察三组黄韧带中BMP-2、VEGF、VDR表达水平。结果LDH和LSS组患者黄韧带中BMP-2表达均高于对照组(P<0.05);LDH和LSS组患者黄韧带中BMP-2表达水平差异无统计学意义(P>0.05)。LDH和LSS组患者黄韧带中VEGF表达均高于对照组(P<0.05),LSS组患者黄韧带中VEGF高于LDH组(P<0.05)。LDH和LSS组患者黄韧带中VDR均低于对照组(P<0.05),LSS组患者黄韧带中VDR表达低于LDH组(P<0.05)。结论LDH和LSS患者黄韧带中BMP-2均呈现高表达;此外,与LDH患者相比,LSS患者黄韧带中表现为VEGF水平升高和VDR水平降低,可能与更严重的炎症和慢性变性相关。Objective To investigate the changes of bone morphogenetic protein(BMP-2),vascular endothelial growth factor(VEGF)and vitamin D receptor(VDR)levels in ligamentum flavum in patients with lumbar degenerative diseases(LDH,LSS).Methods Patients with LSS who underwent surgery in our hospital from January 2019 to December 2021 were selected as LSS group(n=43),patients with LDH as LDH group(n=47),and patients with lumbar fracture who underwent surgery in our hospital during the same period were selected as control group(n=33).The expression levels of BMP-2,VEGF and VDR in LF of the three groups were observed.Results The expression of BMP-2 in LF of LDH and LSS group was significantly higher than that of control group(P<0.05);There was no significant difference in the expression of BMP-2 in LF between LDH and LSS groups(P>0.05).The expression of VEGF in LF of patients with LDH and LSS was significantly higher than that of the control group(P<0.05),and VEGF in LF of LSS group was significantly higher than that of LDH group(P<0.05).The VDR of LF in LDH and LSS group was lower than that in control group(P<0.05).The expression of VDR in LF of LSS group was significantly lower than that of LDH group(P<0.05).Conclusions There was high expression of BMP-2 in ligamenta flavum in LDH and LSS groups,the increase of VEGF and decrease of VDR in the ligamentum flavum of patients with LSS may be related to more serious inflammation and chronic degeneration.

关 键 词：腰椎管狭窄症 腰椎间盘突出症 黄韧带 骨形态发生蛋白 血管生成因子 维生素D受体 

分 类 号：R681.5[医药卫生—骨科学]