抗M3R抗体在干燥综合征并发间质性膀胱炎中致病机制的研究进展  

The pathogenesis of anti-M3R antibody in Sjogrens syndrome complicated with interstitial cystitis

作　　者：徐聪颖 徐智慧[2] 李涯松[3] Xu Congying;Xu Zhihui;Li Yasong(Department of Clinical Medicine,The Second Clinical Medical Collge of Zhejiang Chinese Medical University,Hangzhou 310053,China;Department of Urology,Renmin Hospital of Zhejiang University,Hangzhou 310014.China;Department of Rheumatology Immunology,Renmin Hospial of Zhejiang University,Hanghou 310014,China)

机构地区：[1]浙江中医药大学第二临床学院,杭州310053 [2]浙江省人民医院/杭州医学院附属人民医院泌尿外科,杭州310014 [3]浙江省人民医院/杭州医学院附属人民医院风湿免疫科,杭州310014

出　　处：《中华泌尿外科杂志》2024年第8期637-640,共4页Chinese Journal of Urology

摘　　要：干燥综合征是一种以侵犯泪腺、唾液腺等外分泌腺体为主要临床特点,以高度淋巴细胞浸润为特征的弥漫性结缔组织病。间质性膀胱炎是一种慢性膀胱炎性疾病,以尿频、尿急、夜尿多和/或盆腔疼痛为主要临床表现,其病理改变以膀胱黏膜下溃疡和纤维化为主要表现。干燥综合征并发间质性膀胱炎不少见。抗毒蕈碱型3型乙酰胆碱受体抗体不仅会引起干燥综合征患者腺体分泌功能障碍,同时在间质性膀胱炎中发挥重要的致病作用,其机制可能包括:①伴有肥大细胞参与的免疫性炎症和膀胱感觉神经上调的神经源性炎症;②引起逼尿肌收缩功能受损,诱发三磷酸腺苷释放,刺激感觉神经流出。Sjogren's syndrome is a chronic inflammatory autoimmune disease characterized by invasion of exocrine glands such as lacrimal gland and salivary gland and high lymphocyte infiltration.Interstitial cystitis is a chronic cystitis disease with frequent micturition,urgency,nocturia and/or pelvic pain as its main clinical manifestations,and its pathological changes are bladder submucosal ulcer and fibrosis as its main manifestations.Sjogren's syndrome complicated with interstitial cystitis is not uncommon.Anti-muscarinic type 3 acetylcholine receptor(M3R)antibody will not only cause gland dysfunction,but also play an important role in the pathogenesis of interstitial cystitis.The pathogenesis may include:Immune inflammation accompanied by mast cells and neurogenic inflammation with up-regulation of bladder sensory nerve.②The detrusor contraction function is impaired,which induces ATP release and stimulates sensory nerve outflow.

关 键 词：干燥综合征 间质性膀胱炎 抗毒蕈碱型3型乙酰胆碱受体抗体 致病机制 

分 类 号：R694[医药卫生—泌尿科学]