蓝莓提取物紫檀芪与耐力运动联合对老年高脂血症大鼠脂代谢的影响  

Effects of Pterostilbene Combined with Endurance Exercise on Lipid Metabolism in Elderly Rats with Hyperlipidemia

作　　者：柳志雄 邓晶[1] Liu Zhixiong;Deng Jing(Yichun Vocational Technical College,Yichun,336000)

机构地区：[1]宜春职业技术学院,宜春336000

出　　处：《分子植物育种》2024年第17期5834-5841,共8页Molecular Plant Breeding

摘　　要：本研究旨在探讨蓝莓提取物紫檀芪与耐力运动联合对老年高脂血症大鼠脂代谢的影响。通过建立老年高脂血症大鼠模型,研究了单独耐力运动、不同剂量的紫檀芪处理,以及二者联合应用对肝脏Nrf2/Keap1信号通路的调控作用。结果显示,相比于高脂血模型组,耐力运动与紫檀芪的联合干预显著提高了肝脏nNrf2蛋白的表达量,降低了Keap1蛋白的表达量(P<0.05),发挥了其在调控氧化应激反应和改善脂代谢紊乱方面的潜力。特别是紫檀芪最高剂量联合耐力运动对Nrf2/Keap1通路的激活效果最为显著,突显了紫檀芪与耐力运动的协同作用。此外,本研究还为高脂血症的非药物治疗提供了新的思路。综上所述,紫檀芪与耐力运动的联合应用对老年高脂血症大鼠的脂代谢具有显著改善作用,为进一步开发新型治疗高脂血症的策略提供了科学依据。This study aimed to investigate the effects of pterostilbene extracted from blueberries combined with endurance exercise on lipid metabolism in elderly rats with hyperlipidemia.By establishing a model of elderly hyperlipidemic rats,the study explored the regulatory effects of endurance exercise alone,different doses of pterostilbene treatment,and their combined application on the liver Nrf2/Keap1 signaling pathway.The results showed that compared to the hyperlipidemic model group,the combined intervention of endurance exercise and pterostilbene significantly increased the expression of nNrf2 protein and decreased the expression of Keap1 protein in the liver(P<0.05),indicating its potential in regulating oxidative stress response and improving lipid metabolism disorder.Especially,the activation effect on the Nrf2/Keap1 pathway was most significant in the highest dose of pterostilbene combined with endurance exercise,highlighting the synergistic effect of pterostilbene and endurance exercise.Moreover,this study provides new insights into the non-pharmacological treatment of hyperlipidemia.In conclusion,the combined application of pterostilbene and endurance exercise significantly improves lipid metabolism in elderly rats with hyperlipidemia,offering a scientific basis for developing new strategies to treat hyperlipidemia.

关 键 词：蓝莓提取物 紫檀芪 耐力运动 高脂血症 Nrf2/Keap1信号通路 脂代谢 

分 类 号：R589.2[医药卫生—内分泌]