多光子显微镜在皮肤科中的应用  

Application of multi-photon microscopy in dermatology

作　　者：张嘉琪 吴凡[1] 韩雨晴 刘琦 盘瑶 Zhang Jiaqi;Wu Fan;Han Yuqing;Liu Qi;Pan Yao(Department of Cosmetics,College of Chemistry and Materials Engineering,Beijing Technology and Business University,Beijing 100048,China;Beijing Yiweishi Testing Technology Limited Liability Company,Beijing 100048,China)

机构地区：[1]北京工商大学化学与材料工程学院化妆品系,北京100048 [2]北京颐唯实检测技术有限公司,北京100048

出　　处：《中华皮肤科杂志》2024年第9期857-862,共6页Chinese Journal of Dermatology

摘　　要：多光子显微镜利用近红外激光,通过选择不同的激发波长,使特定皮肤组织中的内源性荧光物或外源性荧光标记物发出荧光,对皮肤组织进行成像。这种在体、无创、精准的三维皮肤成像方法已经应用于皮肤肿瘤、皮肤炎症性疾病、创伤愈合和皮肤衰老等的研究中,是一种有效的成像辅助诊断工具。本文综述了多光子显微镜在皮肤科的应用和进展。Multi-photon microscopy has been used for skin tissue imaging based on the principle that endogenous fluorescent components in specific skin tissues or exogenous fluorescence-labeled substances could emit fluorescence under different excitation wavelengths of near-infrared lasers.It is an effective imaging technique for the auxiliary diagnosis of skin neoplasms,inflammatory skin diseases,wound healing and skin aging,with the advantages of in vivo,non-invasive and accurate three-dimensional skin imaging.This review summarizes the application of and progress in multi-photon microscopy in clinical practice in dermatology.

关 键 词：皮肤肿瘤 皮肤疾病 皮肤衰老 多光子显微镜 皮肤创伤愈合 

分 类 号：R751[医药卫生—皮肤病学与性病学]