注射用头孢曲松钠致儿童输尿管结石及胆囊结石1例分析  

One case of ureterolith combined with gallstone caused by Ceftriaxone sodium for injection in children

作　　者：晁滢 张学梅 张成健 王贝 CHAO Ying;ZHANG Xuemei;ZHANG Chengjian;WANG Bei(Department of pharmacy,Nanjing Tongren Hospital,School of Medicine,Southeast University,Nanjing Jiangsu 211102,China;Department of pediatrics,Nanjing Tongren Hospital,School of Medicine,Southeast University,Nanjing Jiangsu 211102,China)

机构地区：[1]东南大学医学院附属南京同仁医院药学部,江苏南京211102 [2]东南大学医学院附属南京同仁医院儿科,江苏南京211102

出　　处：《中国药物警戒》2024年第8期943-945,共3页Chinese Journal of Pharmacovigilance

摘　　要：目的探讨注射用头孢曲松钠致儿童输尿管结石及胆囊结石的机制,为临床安全合理使用注射用头孢曲松钠提供参考。方法分析患儿接受头孢曲松钠治疗后发生输尿管结石及胆囊结石的诊疗过程,检索同类文献报道,分析其药品不良反应发生机制和临床应对策略。结果患儿使用注射用头孢曲松钠5 d后出现输尿管结石及胆囊结石,停用注射用头孢曲松钠后,输尿管结石自然好转。结合相关文献分析,儿童使用注射用头孢曲松钠后,可能出现输尿管结石及胆囊结石,但大多数停药后可自动消失。结论注射用头孢曲松钠很可能导致患儿输尿管结石及胆囊结石,儿科临床治疗过程中应该予以重视。Objective To explore the mechanism of ceftriaxone injection causing ureterolith and gallstone in children,and provide reference for the safe and reasonable use of ceftriaxone injection in clinical practice.Methods The diagnosis and treatment process of ureterolith and gallstone in the children after receiving treatment with ceftriaxone was analyzed.And Related literature were searched to analyze the mechanism of adverse drug reactions and clinical countermeasures.Results After 5 days of using ceftriaxone,this child developed ureterolith and gallstones.After discontinuing the use of ceftriaxone,ureterolith naturally improved.Based on the analysis of relevant literature,children may develop ureterolith and gallstone after using ceftriaxone,but most of them disappear automatically after discontinuation.Conclusion Ceftriaxone is likely to cause ureterolith and gallstone in children,which deserves more attention in clinic.

关 键 词：注射用头孢曲松钠 输尿管结石 胆囊结石 药品不良反应 儿童 

分 类 号：R978[医药卫生—药品] R994.11[医药卫生—药学]