Multi‑Functional Fibrous Dressings for Burn Injury Treatment with Pain and Swelling Relief and Scarless Wound Healing  

作　　者：Zhengchao Yuan Yue Zhao Muhammad Shafiq Jiahui Song Jing Hou Yuqing Liang Xiao Yu Yujie Chen Fan Yu Mohamed EL‑Newehy Hany EL‑Hamshary Yosry Morsi Shichao Jiang Hui Zheng Xiumei Mo 

机构地区：[1]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative Medicine,College of Biological Science and Medical Engineering,Donghua University,Shanghai 201620,People’s Republic of China [2]Department of Chemical Engineering,Faculty of Engineering,Graduate School,Kyushu University,Fukuoka 819‑0395,Japan [3]United Graduate School of Drug Discovery and Medical Information Sciences,Gifu University,1‑1 Yanagido,Gifu 501‑1193,Japan [4]Department of Orthopedics,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,People’s Republic of China [5]Department of Chemistry,College of Science,King Saud University,P.O.Box 2455,11451 Riyadh,Saudi Arabia [6]Faculty of Engineering and Industrial Sciences,Swinburne University of Technology,Boroondara,VIC 3122,Australia [7]Medical Science and Technology Innovation Center,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250117,People’s Republic of China [8]Department of Thoracic Surgery,Shanghai Pulmonary Hospital,Tongji University School of Medicine,Shanghai 200443,People’s Republic of China

出　　处：《Advanced Fiber Materials》2023年第6期1963-1985,共23页先进纤维材料（英文）

基　　金：Science and Technology Commission of Shanghai Municipality(No.20S31900900,20DZ2254900);Sino German Science Foundation Research Exchange Center(M-0263);Taishan Scholars Program of Shandong Province(tsqn201812141);Shandong Provincial Natural Science Foundation(ZR2021MH004);Academic promotion program of Shandong First Medical University(2019RC016);Researchers Supporting Project Number(RSP2023R65);King Saud University,Riyadh,Saudi Arabia,China Education Association for International Exchange(2022181);Donghua University Postgraduate Innovation and Entrepreneurship Ability Training Program(yjssc2023002);Grant-in-Aid for JSPS Research Fellows(JP21F21353);M.S.is an International Research Fellow of the Japan Society for the Promotion of Science(Postdoctoral Fellowships for Research in Japan(Standard));M.S.is keenly grateful to the Gifu University,Japan for Special Cooperative Research Program and College of Biological Science and Medical Engineering,Donghua University,Shanghai,China for cooperative research.

摘　　要：As one of the most common forms of skin injuries,skin burns are often accompanied by edema pain,suppuration of infection,slow tissue regeneration,and severe scar formation,which significantly delay wound healing as well as affect the quality of life.We prepared multifunctional electrospun poly(L-lactide-co-glycolide)/gelatin(P/G)-based dressings to synergistically harness the therapeutic benefits of peppermint essential oil(T),burn ointment(B),and Oregano essential oil(O)(P/G@TBO)for skin regeneration in punch and burn injury models.The P/G@TBO can afford the sustained release of bioactive cues for up to 72 h as well as remarkably promote cell migration(ca.P/G@TBO,89%vs.control group,51%)at 24 h.The P/G@TBO membranes also showed significant angiogenic effect as well as antibacterial and anti-inflammatory properties than that of the control group in vitro.Moreover,P/G@TBO dressings enabled fast wound healing(ca.P/G@TBO,100%wound closure vs.control group,95%)in a full-thickness excisional defect model up to 14 days in rats.Further evaluation of membranes in different animal models,including tail wagging model,facial itch model,and hot burn injury model showed significant pain relieve effect as well as itching and swelling relief functions during earlier stages of wound healing.Membranes were next transplanted into a scalded wound model in rats and an ear punch wound model in rabbits,which manifested antibacterial and anti-inflammatory properties and promoted re-epithelialization to achieve scarless wound healing percentage wound closure at day 28:P/G@TBO,96%vs.control group 66%.Taken together our approach of simultaneously harnessing T,B,and O to enable multifunctionality to fibrous dressings may hold great promise for burn wound healing applications and other related disciplines.

关 键 词：Burn injury Wound healing Skin regeneration Pain and swelling relief Nanofiber membrane 

分 类 号：R644[医药卫生—外科学]