替加环素联合美罗培南治疗重症腹腔感染的效果及其对血常规、血生化指标的影响  

The Effect of Tigecycline Combined with Meropenem in the Treatment of Severe Abdominal Infection and Its Impact on Blood Routine and Biochemical Indicators

作　　者：叶家茂 YE Jiamao(Department of Critical Care Medicine,Yangzhou Traditional Chinese Medicine Hospital,Yangzhou 225000,Jiangsu,China)

机构地区：[1]江苏省扬州市中医院重症医学科,江苏扬州225000

出　　处：《中外医疗》2024年第21期109-112,共4页China & Foreign Medical Treatment

摘　　要：目的分析在重症腹腔感染中联合使用替加环素、美罗培南的效果及其对血常规、血生化指标的改善作用。方法便利选取2020年3月—2023年12月江苏省扬州市中医院收治的97例重症腹腔感染病患者为研究对象,根据治疗方法不同分为对照组(48例)和观察组(49例)。对照组予以美罗培南治疗,观察组予以替加环素联合美罗培南治疗,比较两组患者治疗后各生理指标、血常规及生化指标、免疫球蛋白水平的改善情况。结果治疗后,观察组生理指标中体温(36.81±0.60)℃、呼吸频率(16.74±2.52)次/min、心率(75.42±5.82)次/min均低于对照组的(37.34±0.65)℃、(18.41±2.71)次/min、(80.56±6.03)次/min,收缩压(112.54±12.17)mmHg和舒张压(74.06±5.41)mmHg均高于对照组(104.41±12.06)mmHg、(71.31±5.52)mmHg,差异有统计学意义(t=4.174、3.144、4.272、3.304、2.478,P均<0.05);对照组血常规、生化指标均差于观察组,差异有统计学意义(P均<0.05);对照组免疫球蛋白含量低于观察组,差异有统计学意义(P<0.05)。结论对于重症腹腔感染患者而言,联合使用替加环素、美罗培南治疗可改善生理功能、血常规及血生化指标,提升免疫力。Objective To analyze the effect of combined use of tigecycline and meropenem in severe abdominal infection and its improvement on blood routine and blood biochemical indexes.Methods A total of 97 patients with severe abdominal infection admitted to Yangzhou Hospital of Traditional Chinese Medicine of Jiangsu Province from March 2020 to December 2023 were conveniently selected as the research objects.They were divided into control group(48 cases)and observation group(49 cases)by different treatment method.The control group was treated with meropenem,and the observation group was treated with tigecycline combined with meropenem.The improvement of all aspects after treatment was compared between the two groups.Results After treatment,the body temperature(36.81±0.60)°C,respiratory rate(16.74±2.52)times/min and heart rate(75.42±5.82)times/min in the observation group were lower than(37.34±0.65)℃,(18.41±2.71)times/min and(80.56±6.03)times/min in the control group,the systolic blood pressure(112.54±12.17)mmHg and diastolic blood pressure(74.06±5.41)mmHg were higher than(104.41±12.06)mmHg and(71.31±5.52)mmHg in the control group,and the differences were statistically significant(t=4.174,3.144,4.272,3.304,2.478,all P<0.05);the blood routine and biochemical indexes of the control group were worse than those of the observation group,and the differences were statistically significant(both P<0.05).The immunoglobulin in the control group was lower than that in the observation group,and the difference was statistically significant(P<0.05).Conclusion For patients with severe abdominal infection,the combined use of tigecycline and meropenem can improve physiological function,blood routine and blood biochemical indicators,and improve immunity.

关 键 词：重症腹腔感染 替加环素 美罗培南 血常规 血生化 免疫球蛋白 

分 类 号：R4[医药卫生—临床医学]