Recent biotechnological advances and future prospective of Bacillus licheniformis as microbial cell factories  

作　　者：Hehe He Yupeng Zhang Guiyang Shi Youran Li 

机构地区：[1]Key Laboratory of Industrial Biotechnology,Ministry of Education,Jiangnan University,1800 Lihu Avenue,Wuxi 214000,Jiangsu,People’s Republic of China [2]National Engineering Research Center of Cereal Fermentation and Food Biomanufacturing,Jiangnan University,1800 Lihu Avenue,Wuxi 214000,Jiangsu,People’s Republic of China [3]Jiangsu Provisional Research Center for Bioactive Product Processing Technology,Jiangnan University,1800 Lihu Avenue,Wuxi 214122,Jiangsu Province,People’s Republic of China

出　　处：《Systems Microbiology and Biomanufacturing》2023年第4期521-532,共12页系统微生物学与生物制造（英文）

基　　金：supported by National Key Research&Development Program of China(2018YFA0900504,2020YFA0907700,and 2018YFA0900300);the National Natural Foundation of China(31401674);the National First-Class Discipline Program of Light Industry Technology and Engineering(LITE2018-22);the Top-notch Academic Programs Project of Jiangsu Higher Education Institutions.

摘　　要：Bacillus licheniformis is a characteristic Gram-positive bacterium originally found in soil.This microorganism has long been utilised as a workhorse for production of industrial enzymes or high value-added chemicals.With ever-increasing understand-ing on this strain and the maturation of the genetic technique,important advances have recently been made in developing B.licheniformis as an excellent chassis cell for synthetic biology.Here,we provide an overview of updated understanding on genome information,anaerobic metabolism,industrial applications of this strain.The state-of-art B.licheniformis genetics,especially its synthetic biology advances in biosensor,expression system and artificial metabolic pathways are illustrated.Finally,perspectives are offered for the limitations and challenges to be addressed to improve B.licheniformis as microbial cell factories.

关 键 词：Bacillus licheniformis Industrial application Biomanufacturing Synthetic biology 

分 类 号：Q93[生物学—微生物学]