针灸干预慢性失眠障碍的脑网络机制研究进展  

Research progress in brain network connectivity mechanism of acupuncture andmoxibustion intervention for chronic insomnia disorder

作　　者：吴倩[1] 温秀云 林德晖 王舢泽 梁雪松 符文彬[1] WU Qian;WEN Xiuyun;LIN Dehui;WANG Shanze;LIANG Xuesong;FU Wenbin(The Second Affi liated Hospital of Guangzhou University of Chinese Medicine/Guangdong Provincial Hospital of Chinese Medicine,Guangzhou 510120,China;Guangdong Pharmaceutical University,Guangzhou 510006,China)

机构地区：[1]广州中医药大学第二附属医院/广东省中医院,广州510120 [2]广东药科大学,广州510006

出　　处：《长春中医药大学学报》2024年第9期1044-1048,共5页Journal of Changchun University of Chinese Medicine

基　　金：国家自然科学基金面上项目及区域联合重点项目(81804199&U23A20507&82104991);广东省重点领域研发计划一岭南中医药现代化重点专项(2020B1111100007);广东省中医药高质量发展传承创新提升工程专项(粤财社[2022]102号);广州中医药大学“双一流”与高水平大学学科协同创新团队项目(2021xk22);广东省中医药局符文彬广东省名中医传承工作室(粤中医办函[2020]1号);广东省中医院朝阳人才科研专项资助(ZY2022KY14);广东省中医药科学院资助项目(YN2023MS25)。

摘　　要：慢性失眠障碍为临床常见病症,严重影响患者的生活质量。针灸已被证实能提升失眠障碍患者的睡眠质量,然而其效应机制尚未清楚。脑影像研究表明,慢性失眠障碍患者存在大脑网络功能连接的特异性改变,尤其体现在默认模式网络(DMN)、突显网络(SN)、认知控制网络(CCN)、负性情绪网络(AN)的脑网络内部以及网络之间的连接性上。这为探索针灸脑网络神经机制提供了新的切入点。本文回顾了慢性失眠伴障碍的大脑网络连接的变化特征以及针灸干预对其脑网络连接的改变,旨在为深入探讨针灸治疗慢性失眠障碍的潜在机制提供理论依据和未来研究展望。Chronic insomnia disorder is a common clinical disorder that seriously affects the quality of life of the patients.Acupuncture and moxibustion have been proven to improve the sleep quality of patients with insomnia disorders,but the mechanisms are still unclear.Brain imaging studies have shown that patients with chronic insomnia disorders exhibit specific changes in functional connectivity within the brain networks,especially reflected in the internal connections of the four brain networks of default mode network(DMN),salience network(SN),cognitive control network(CCN),and negative emotion network(NEN),as well as the connections between the networks of these four brain networks.This provides a new entry point for exploring the neural mechanisms of acupuncture and moxibustion on the brain network.This review summarizes the characteristics of changes in brain network connectivity of chronic insomnia with disorders and the changes in brain network connectivity caused by acupuncture and moxibustion intervention,so as to provide theoretical basis for further exploring the potential mechanisms of acupuncture and moxibustion treatment of chronic insomnia disorder.

关 键 词：针灸 慢性失眠障碍 脑功能 脑网络连接性 机制 综述 

分 类 号：R246.6[医药卫生—针灸推拿学]