铁皮石斛的化学成分及药理作用研究进展  

Advance on chemical components and pharmacological effects of Dendrobium officinale

作　　者：张石玉 龚小见[1,2] 周欣 穆应素[1,2] 陈华国 梁康 周美[4] 赵超 ZHANG Shiyu;GONG Xiaojian;ZHOU Xin;MU Yingsu;CHEN Huaguo;LIANG Kang;ZHOU Mei;ZHAO Chao(Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment,Gui zhou Normal University,Guiyang 550001,China;Guizhou Engineering Laboratory for Quality Control and Evalu ation Technology of Medicine,Guizhou Normal University,Guiyang 550001,China;Guizhou Provincial Academyof Forestry,Guiyang 550000,China;Key Laboratory of Chemistry for Natural Products of Guizhou Province andChinese Academy of Sciences,Guiyang 550002,China)

机构地区：[1]贵州师范大学,贵州省山地环境信息系统与生态环境保护重点实验室,贵州贵阳550001 [2]贵州师范大学,贵州省药物质量控制及评价技术工程实验室,贵州贵阳550001 [3]贵州省林业科学研究院,贵州贵阳550000 [4]贵州省中国科学院天然产物化学重点实验室,贵州贵阳550002

出　　处：《甘肃农业大学学报》2024年第4期257-278,共22页Journal of Gansu Agricultural University

基　　金：贵州省林业科研项目[黔林科合(2021)12号];贵州省高层次创新人才培养项目[黔科合人才(2015)4033号];贵州省农村产业革命石斛产业发展专项资金。

摘　　要：铁皮石斛(Dendrobium officinale Kimura et Migo)是兰科石斛属多年生草本植物铁皮石斛的干燥茎,药用历史悠久,在我国南部地区广泛分布。研究表明铁皮石斛不同部位(叶、茎、花)富含黄酮、联苄、生物碱、苯丙素、萜、菲与核苷类化合物,具有显著的抗氧化、抗肿瘤、降血糖、缓解便秘、预防骨质疏松、护肝保肾等药理活性,在治疗恶性肿瘤、胃肠道疾病、糖尿病、白内障、关节炎、血栓闭塞性脉管炎及慢性咽炎等疾病有很好的疗效,特别是对于胃癌、肝癌、干眼症以及糖尿病等疾病的缓解作用比较显著。本文将铁皮石斛中报道的261种化合物、药理作用研究现状进行综述,以期为铁皮石斛后续研究开发参考。Tie-Pi Shihu,the dried stem of the perennial herb Dendrobium officinale in the genus Den⁃drobium of the family Orchidaceae,has a long history of medicinal usage and is widely distributed in the southern part of China.Researches showed that different parts(leaves,stems and flowers)of D.officinale are rich in flavonoids,bibenzyl,alkaloids,phenylpropanoids,terpenes,phenanthrene and nucleosides,which have significant pharmacological activities such as antioxidant,antitumor,hypoglycemic,constipation relief,osteoporosis prevention,liver and kidney protection,etc..They are very effective in treating malignant tumor,gastrointestinal diseases,diabetes,cataract,arthritis,thromboangiitis obliterans and chronic pharyngitis,etc.Particularly,it is effective in the treatments of gastric cancer,liver cancer,dry eye and diabetes.In this paper,the reported 261 compounds from Dendrobium officinale and the progress of research on pharmacological effects are reviewed,providing the reference for subsequent research and development of Dendro⁃bium officinale.

关 键 词：铁皮石斛 化学成分 药理作用 临床应用 

分 类 号：R282[医药卫生—中药学]