柴术理胃饮联合多潘立酮治疗老年脾虚气滞型FD伴睡眠障碍临床研究  

Clinical Study of Chaizhu Liwei Yin Combined with Domperidone in the Treatment of Elderly Patients with Spleen Deficiency Qi Stagnation FD and Sleep Disorder

作　　者：范明明 张艺川 刘永梅 常雨 张艮霜 李显筑 FAN Mingming;ZHANG Yichuan;LIU Yongmei(Heilongjiang Academy of Traditional Chinese Medicine,Heilongjiang 150036,China)

机构地区：[1]黑龙江省中医药科学院,哈尔滨150036

出　　处：《医学研究杂志》2024年第8期137-140,共4页Journal of Medical Research

基　　金：黑龙江省自然科学基金资助项目(LH2023H079);博士后基金资助项目(040102-438);黑龙江省中医药科研项目(ZHY2022-084);黑龙江省卫生健康委科研课题项目(20222121010688)。

摘　　要：目的观察柴术理胃饮联合多潘立酮治疗老年脾虚气滞型功能性消化不良(functional dyspepsia,FD)伴睡眠障碍的临床疗效。方法选取2020年9月~2022年9月黑龙江省中医药科学院南岗院区老年病门诊收治的80例脾虚气滞型FD伴睡眠障碍的老年患者为研究对象,随机分为观察组和对照组,每组各40例。观察组给予多潘立酮片联合柴术理胃饮治疗,对照组给予多潘立酮片治疗,两组均连续给药4周。观察治疗前后两组老年FD患者的临床疗效、中医证候疗效评价评分、尼平消化不良指数(Nepean dyspepsia index,NDI)、匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)变化差异。结果治疗过程中,对照组脱落1例,观察组脱落2例,最终77例纳入疗效观察统计,其中对照组39例,观察组38例。治疗后,观察组和对照组临床症状总有效率分别为86.84%和69.23%,观察组优于对照组(P<0.05);观察组和对照组中医证候疗效评价评分均低于治疗前(P<0.05),观察组低于对照组(P<0.05);观察组NDI评分(77.13±5.62分)和对照组NDI评分(61.03±5.33分)均较治疗前提升(P<0.05),且观察组提升幅度高于对照组(P<0.05);观察组PSQI总分(5.23±1.52分)和对照组PSQI总分(7.74±2.17分)均低于治疗前(P<0.05),观察组低于对照组(P<0.05);观察期间,观察组与对照组均无明显不良反应,安全性较高。结论柴术理胃饮联合多潘立酮能有效缓解老年脾虚气滞型FD患者的胃肠道症状,改善睡眠状态,提高老年患者的生活质量。Objective To observe the clinical efficacy of chaizhu liwei yin combined with domperidone in the treatment of functional dyspepsia(FD)with spleen deficiency and qi stagnation stype accompanied by sleep disorders.Methods A total of 80 elderly patients with FD with spleen deficiency and qi stagnation stype accompanied by sleep disorders in the Geriatric Clinic,Nangang Hospital of Heilongjiang Academy of Chinese Medicine from September 2020 to September 2022 were selected as the research objects,and they were randomly divided into the observation group and the control group,with 40 cases in each group.The observation group was treated with domperidone tablets combined with chaizhu liwei yin,while the control group was treated with domperidone tablets,the patients in the two groups were given continuous administration for 4 weeks.The clinical efficacy,TCM syndrome efficacy evaluation score,Nepean dyspepsia index(NDI)and Pittsburgh sleep quality index(PSQI)were observed before and after treatment in the two groups of elderly FD patients.Results During the treatment,1 case was shed in the control group and 2 cases in the observation group.77 patients were included in the curative effect observation statistics,including 39 cases in the control group and 38 cases in the observation group.After treatment,the total effective rate of clinical symptoms in the observation group and the control group was 86.84% and 69.23%,respectively,and the observation group was better than the control group(P<0.05).the scores of TCM syndrome efficacy evaluation in observation group and control group were lower than before treatment(P<0.05),and the observation group was lower than the control group(P<0.05);NDI scores of the observation group(77.13±5.62)and control group(61.03±5.33)were both improved compared with before treatment(P<0.05),and the improvement of the observation group was higher than that of the control group(P<0.05);the total scores of PSQI in the observation group(5.23±1.52)and control group(7.74±2.17)were lower than befo

关 键 词：功能性消化不良 柴术理胃饮 睡眠障碍 脾虚气滞 疏木培土 

分 类 号：R259[医药卫生—中西医结合]