糖皮质激素不同给药方式治疗慢性阻塞性肺疾病急性加重期患者的临床疗效比较  

Comparison of Clinical Efficacy of Different Administration Modes of Glucocorticoids in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：姚福朵 翟峰 朱娇 YAO Fuduo;ZHAI Feng;ZHU Jiao(Department of Internal Medicine,Pizhou Hospital of Traditional Chinese Medicine,Pizhou 221300,Jiangsu,China)

机构地区：[1]邳州市中医院内科,江苏邳州221300

出　　处：《系统医学》2024年第14期84-87,共4页Systems Medicine

摘　　要：目的分析慢性阻塞性肺疾病急性加重期(acute exacerbation chronic obstructive pulmonary disease,AECOPD)治疗中糖皮质激素给药方式差异对疗效的影响。方法目的选取2021年6月—2023年5月邳州市中医院接受治疗的70例AECOPD患者,以给药方式不同分为两组,采取糖皮质激素口服用药的35例为口服组,采取糖皮质激素静脉滴注用药的35例为静滴组;比较两组治疗效果、预后指标、肺功能及不良反应。结果静滴组治疗总有效率较口服组略高,但差异无统计学意义(P>0.05)。治疗前后两组预后指标比较,差异无统计学意义(P均>0.05)。治疗前后,静滴组用力肺活量、最大呼吸峰流速、第1秒用力呼气容积与口服组相比,差异无统计学意义(P均>0.05)。口服组不良反应发生率为5.71%(2/35),较静滴组的22.86%(8/35)更低,差异有统计学意义(χ^(2)=4.200,P<0.05)。结论予以AECOPD患者糖皮质激素口服及静脉滴注用药均可发挥良好作用,可改善患者肺功能及预后,但二者相较,以静滴用药效果更佳,口服用药安全性更高。Objective To analyze the effect of differences administration mode of glucocorticoid in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods 70 patients with AECOPD who received treatment in Pizhou Hospital of Traditional Chinese Medicine from June 2021 to May 2023 were objectively selected and divideded into two groups different adminisstrain modes.35 patients receiving oral glucocorticoids were in the oral group and 35 patients receiving intravenous glucocorticoids were in the intravenous drip group.Compare the therapeutic effect,prognostic index,lung function and adverse reactions between the two groups.Results The total effective rate of intravenous drip group was slightly higher than that of oral group,and the difference was not statistically significant(P>0.05).There was no statistically significant difference in prognostic indexes between the two groups before and after treatment(all P>0.05).Before and modes treatment,there was no statistically significant difference in forced vital capacity,maximum peak respiratory flow rate,forced expiratory volume in one second between intravenous drip group and oral group(all P>0.05).The oral group's incidence of adverse reactions was 5.71%(2/35),lower than 22.86%(8/35)in the intravenous group,the difference was statistically significant(χ^(2)=4.200,P<0.05).Conclusion Both oral and intravenous administration of glucocorticoids can play a good role in improving lung function and prognosis of patients with AECOPD,but compared with the two,the effect of intravenous administration is better,and oral administration is safer.

关 键 词：慢性阻塞性肺疾病 急性加重期 糖皮质激素 口服用药 静脉滴注 并发症 

分 类 号：R563[医药卫生—呼吸系统]