葛根素治疗肺动脉高压作用机制研究进展  

Research progress on the mechanism of puerarin in pulmonary hypertension

作　　者：于淼 祝田田 YU Miao;ZHU Tiantian(College of Pharmacy,Xinxiang Medical University,Xinxiang 453003,Henan Province,China)

机构地区：[1]新乡医学院药学院,河南新乡453003

出　　处：《新乡医学院学报》2024年第9期895-900,共6页Journal of Xinxiang Medical University

基　　金：国家自然科学基金资助项目(编号:81800051);河南省科技攻关项目(编号:212102310319);河南省自然科学基金面上项目(编号:242300421305)。

摘　　要：肺动脉高压(PH)是一种以肺动脉压力和肺血管阻力持续升高为特征的心血管疾病,其病理基础是肺血管的重构。葛根素作为葛根中的主要活性成分,已被证实具有显著的心血管保护作用,其机制可能是降低炎症反应、氧化应激和心肌细胞凋亡。本文将对葛根素在PH治疗中的分子机制研究进展进行综述,以期为PH的临床治疗提供新的策略和理论依据。Pulmonary hypertension(PH)is a cardiovascular disease characterized by persistent elevation of pulmonary artery pressure and pulmonary vascular resistance,and its pathological basis is remodeling of the pulmonary vasculature.Puerarin,the main active ingredient in Pueraria Mirifica,has been shown to have significant cardioprotective effects,and its mechanism may be to reduce inflammatory response,oxidative stress,and myocardial cell apoptosis.This paper reviews the research progress on the molecular mechanism of puerarin in the treatment of PH,with the aim of providing new strategies and theoretical basis for the clinical treatment of PH.

关 键 词：肺动脉高压 葛根素 作用机制 

分 类 号：R285.5[医药卫生—中药学]