肠道微生态在慢性肾脏病中的研究进展  

Research progress on intestinal microecological in chronic kidney disease

作　　者：朱琳 牛洁 肖兰 尹凌云 于洋洋 王羽晴 周萍 Zhu Lin;Niu Jie;Xiao Lan;Yin Lingyun;Yu Yangyang;Wang Yuqing;Zhou Ping(Department of Pediatric Nephrology and Rheumatology,Sichuan Clinical Research Center for Pediatric Nephrology,Sichuan Provincial Maternity and Child Health Care Hospital,The Affiliated Women's and children's Hospital of Chengdu Medical College,Chengdu 610031,China;Department of Pediatrics,Chengdu Boe Hospital,Chengdu 610000,China;Department of Pediatrics,Jilin Children's Hospital in Jilin Province,Jilin 132000,China;Department of Clinical Skills Center Affiliated to Harbin Medical University Affiliated Cancer Hospital,Harbin 150081,China)

机构地区：[1]四川省妇幼保健院、成都医学院附属妇女儿童医院儿童肾脏风湿免疫科、四川省儿童肾病临床医学研究中心,610031 [2]成都京东方医院儿科,610000 [3]吉林省吉林市儿童医院儿科,132000 [4]哈尔滨医科大学附属肿瘤医院临床技能中心,150081

出　　处：《中国小儿急救医学》2024年第8期632-636,共5页Chinese Pediatric Emergency Medicine

基　　金：四川省科技厅2022年重点研发计划(2022YFS0149);2023年四川省卫生健康委员会科技项目(23LCYJ015);成都医学院2022年度学校科技基金(CYZYB22-08);四川省妇幼保健院2023年院内创新基金(CXZD2023-05)。

摘　　要：慢性肾脏病(CKD)对全球公共健康有重大的影响,是导致非传染性疾病的发病率和病死率上升的重要因素之一。肠道微生态参与机体免疫、营养物质吸收等多种病理生理活动。随着2002年肠-肾轴这一概念的提出,研究者发现肾小球滤过率的下降导致尿毒症毒素在肠道中蓄积,破坏肠道黏膜屏障,导致尿毒症毒素易位,激活全身氧化应激反应进一步促进CKD的进展。本文综述了肠道微生物群的功能、肠-肾轴以及微生物制剂在慢性肾脏病中的应用。Chronic kidney disease(CKD)has a significant impact on global public health and is one of the important factors leading to the rise of incidence rate and mortality of non communicable diseases.Intestinal microecology is involved in many pathophysiological activities,such as immunity and nutrient absorption.With proposal of the concept of intestine-kidney axis in 2002,researchers found that the decline of glomerular filtration rate led to accumulation of uremic toxins in intestine,destroyed the intestinal mucosal barrier,led to the translocation of toxins,activated the systemic oxidative stress response,further promoted the progress of CKD.This article reviewed the function of gut microbiota,intestine-gut kidney axis,and the application of microbial preparations in CKD.

关 键 词：慢性肾脏病 肠-肾CKD轴 肠道微生态 肠道黏膜屏障 肠道微生态制剂 

分 类 号：R726.9[医药卫生—儿科]