A homogeneous dopamine-silver nanocomposite coating:striking a balance between the antibacterial ability and cytocompatibility of dental implants  

作　　者：Shuang Wang Zichen Wu Yankai Wang Huilei Hong Lijie Zhang Zhaoyang Chen Pengkang Zhang Zirui Chen Weibo Zhang Shunli Zheng Quanli Li Wei Li Xiangyang Li Hua Qiu Jialong Chen 

机构地区：[1]Key Laboratory of Oral Diseases Research of Anhui Province,Stomatologic Hospital and College,Anhui Medical University,Hefei,Anhui 230032,China

出　　处：《Regenerative Biomaterials》2023年第1期15-28,共14页再生生物材料（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.31670967,32000932 and 82061160492);the Key Research and Development Projects in Anhui Province(No.202104j07020039 and 2022e07020051);the Scientific Research Foundation of the Institute for Translational Medicine of Anhui Province(No.2021zhyx-C51 and No.2021zhyx-C68);2020 Disciplinary Construction Project in School of Dentistry,Anhui Medical University(No.2020kqkyT01,2020kqkyT03 and 2020kqsy09);2021 Disciplinary Construction Project in School of Dentistry,Anhui Medical University(No.2021kqxkFY13 and 2021kqxkFY16);Key Project of Natural Science Research of the Anhui Provincial Department of Education(No.KJ2019A0251 and KJ2021A0270);Anhui Provincial Natural Science Foundation(No.2208085QE136 and 2008085QH374).

摘　　要：Silver has been widely used for surface modification to prevent implant-associated infections.However,the inherent cytotoxicity of silver greatly limited the scope of its clinical applications.The construction of surfaces with both good antibacterial properties and favorable cytocompatibility still remains a challenge.In this study,a structurally homogeneous dopamine-silver(DA/Ag)nanocomposite was fabricated on the implant surface to balance the antibacterial activity and cytocompatibility of the implant.The results show that the DA/Ag nanocomposites prepared under the acidic conditions(pH=4)on the titanium surface are homogeneous with higher Ag^(+)content,while an obvious core(AgNPs)-shell(PDA)structure is formed under neutral(pH=7)and alkaline conditions(pH=10),and the subsequent heat treatment enhanced the stability of PDA-AgNPs nanocomposite coatings on porous titanium.The antibacterial test,cytotoxicity test,hypodermic implantation and osteogenesis test revealed that the homogeneous PDA-AgNPs nanocomposite coating achieved the balance between the antibacterial ability and cytocompatibility,and had the best outcomes for soft tissue healing and bone formation around the implants.This study provides a facile strategy for preparing silver-loaded surfaces with both good antibacterial effect and favorable cytocompatibility,which is expected to further improve the therapeutic efficacy of silver composite-coated dental implants.

关 键 词：titanium implants ANTIBACTERIAL CYTOCOMPATIBILITY SILVER nanocomposites 

分 类 号：R318[医药卫生—生物医学工程] TB383[医药卫生—基础医学]