Inhalable microparticles as drug delivery systems to the lungs in a dry powder formulations  

作　　者：Karolina Knap Konrad Kwiecien Katarzyna Reczynska-Kolman Elzbieta Pamuła 

机构地区：[1]Department of Biomaterials and Composites,Faculty of Materials Science and Ceramics,AGH University of Science and Technology,30-059 Krakow,Poland

出　　处：《Regenerative Biomaterials》2023年第1期218-248,共31页再生生物材料（英文版）

基　　金：supported by the National Science Centre,Poland(project No 2019/35/B/ST5/01103);by the Program‘Excellence Initiative-Research University’for the AGH University of Science and Technology。

摘　　要：Inhalation-administrated drugs remain an interesting possibility of addressing pulmonary diseases.Direct drug delivery to the lungs allows one to obtain high concentration in the site of action with limited systemic distribution,leading to a more effective therapy with reduced required doses and side effects.On the other hand,there are several difficulties in obtaining a formulation that would meet all the criteria related to physicochemical,aerodynamic and biological properties,which is the reason why only very few of the investigated systems can reach the clinical trial phase and proceed to everyday use as a result.Therefore,we focused on powders consisting of polysaccharides,lipids,proteins or natural and synthetic polymers in the form of microparticles that are delivered by inhalation to the lungs as drug carriers.We summarized the most common trends in research today to provide the best dry powders in the right fraction for inhalation that would be able to release the drug before being removed by natural mechanisms.This review article addresses the most common manufacturing methods with novel modifications,pros and cons of different materials,drug loading capacities with release profiles,and biological properties such as cytocompatibility,bactericidal or anticancer properties.

关 键 词：pulmonary therapies drug delivery systems to lungs MICROPARTICLES INHALERS dry powder inhalers 

分 类 号：R318[医药卫生—生物医学工程]