Superstable homogeneous lipiodol-ICG formulation:initial feasibility and first-in-human clinical application for ruptured hepatocellular carcinoma  

作　　者：Yongfu Xiong Pan He Yang Zhang Hu Chen Yisheng Peng Peng He Jie Tian Hongwei Cheng Gang Liu Jingdong Li 

机构地区：[1]Department of Hepatobiliary Surgery,Academician(Expert)Workstation,Affiliated Hospital of North Sichuan Medical College,Nanchong 637600,China [2]State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen 361102,China [3]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province,Luzhou 646000,China [4]Key Laboratory of Molecular Imaging,Institute of Automation,Chinese Academy of Sciences,Beijing 100190,China

出　　处：《Regenerative Biomaterials》2023年第1期326-332,共7页再生生物材料（英文版）

基　　金：supported by the National Key R&D Program of China(2019YFA0110600).

摘　　要：The most common treatment of spontaneous tumor rupture hemorrhage(STRH)is transcatheter arterial embolization(TAE)followed by liver resection,and surgical navigation using near-infrared fluorescence is effective method for detecting hidden lesions and ill-defined tumor boundaries.However,due to the blockage of the tumor-supplying artery after effective TAE treatment,it is difficult to deliver sufficient fluorescent probes to the tumor region.In this study,we report on the successful application of superstable homogeneous intermixed formulation technology(SHIFT)in precise conversion hepatectomy for ruptured hepatocellular carcinoma(HCC).A homogeneous lipiodol-ICG formulation obtained by SHIFT(SHIFT-ICG)was developed for clinical practice for STRH.A ruptured HCC patient received the combined protocol for embolization and fluorescence surgical navigation and exhibited excellent hemostatic effect.Lipiodol and ICG were both effectively deposited in the primary lesion,including a small metastatic lesion.In follow-up laparoscopic hepatectomy,SHIFT-ICG could clearly and precisely image the full tumor regions and boundaries in real time,and even indistinguishable satellite lesions still expressed a remarkable fluorescence intensity.In conclusion,the simple and green SHIFT-ICG formulation can be effectively used in emergency embolization hemostasis and later precise fluorescence navigation hepatectomy in patients with ruptured HCC bleeding and has high clinical application value.

关 键 词：conversion therapy fluorescent navigation HEPATECTOMY spontaneous tumor rupture 

分 类 号：R318[医药卫生—生物医学工程]