Osteochondral regenerative engineering:challenges,state-of-the-art and translational perspectives  

作　　者：Srimanta Barui Debolina Ghosh Cato T.Laurencin 

机构地区：[1]Connecticut Convergence Institute for Translation in Regenerative Engineering,University of Connecticut Health Center,Farmington,CT 06030,USA [2]Department of Orthopaedic Surgery,University of Connecticut Health Center,Farmington,CT 06030,USA [3]Department of Chemical and Biomolecular Engineering,University of Connecticut,Storrs,CT 06269,USA [4]Department of Biomedical Engineering,University of Connecticut,Storrs,CT 06269,USA [5]Department of Materials Science and Engineering,University of Connecticut,Storrs,CT 06269,USA

出　　处：《Regenerative Biomaterials》2023年第1期354-376,共23页再生生物材料（英文版）

基　　金：supported by the Raymond and Beverly Sackler Center for Biomedical,Biological,Physical and Engineering Sciences.

摘　　要：Despite quantum leaps,the biomimetic regeneration of cartilage and osteochondral regeneration remains a major challenge,owing to the complex and hierarchical nature of compositional,structural and functional properties.In this review,an account of the prevailing challenges in biomimicking the gradients in porous microstructure,cells and extracellular matrix(ECM)orientation is presented.Further,the spatial arrangement of the cues in inducing vascularization in the subchondral bone region while maintaining the avascular nature of the adjacent cartilage layer is highlighted.With rapid advancement in biomaterials science,biofabrication tools and strategies,the state-of-the-art in osteochondral regeneration since the last decade has expansively elaborated.This includes conventional and additive manufacturing of synthetic/natural/ECM-based biomaterials,tissue-specific/mesenchymal/progenitor cells,growth factors and/or signaling biomolecules.Beyond the laboratory-based research and development,the underlying challenges in translational research are also provided in a dedicated section.A new generation of biomaterial-based acellular scaffold systems with uncompromised biocompatibility and osteochondral regenerative capability is necessary to bridge the clinical demand and commercial supply.Encompassing the basic elements of osteochondral research,this review is believed to serve as a standalone guide for early career researchers,in expanding the research horizon to improve the quality of life of osteoarthritic patients affordably.

关 键 词：osteochondral regeneration additive manufacturing gradient porosity in vivo COMMERCIALIZATION 

分 类 号：R318[医药卫生—生物医学工程]