A novel biomimetic trabecular bone metal plate for bone repair and osseointegration  

作　　者：Zhijie Ma Baoyi Liu Shuqiang Li Xiaohu Wang Jingyu Li Jiahui Yang Simiao Tian Chengjun Wu Dewei Zhao 

机构地区：[1]Orthopaedic of Department,Affiliated ZhongShan Hospital of Dalian University,Dalian,Liaoning 116001,China [2]Orthopaedic of Department,The Fourth People’s Hospital of Guiyang,Guiyang,Guizhou 550000,China [3]School of Biomedical Engineering,Faculty of Electronic Information and Electrical Engineering,Dalian University of Technology,Dalian,Liaoning 116024,China

出　　处：《Regenerative Biomaterials》2023年第1期423-431,共9页再生生物材料（英文版）

基　　金：supported by the National Natural Science Foundation of China[82172398];Dalian Medical Key Specialty‘Dengfeng Plan’Construction Project and China Postdoctoral Science Foundation[2022M720616].

摘　　要：Fracture is one of the most common traumatic diseases in clinical practice,and metal plates have always been the first choice for fracture treatment because of their high strength.However,the bone plates have high elastic modulus and do not match the biomechanics of human bone,which adversely affects callus formation and fracture healing.Moreover,the complex microenvironment in the human body can induce corrosion of metallic materials and release toxic ions,which reduces the biocompatibility of the bone plate,and may necessitate surgical removal of the implant.In this study,tantalum(Ta)was deposited on porous silicon carbide(SiC)scaffolds by chemical vapor deposition technology to prepare a novel porous tantalum(pTa)trabecular bone metal plate.The function of the novel bone plate was evaluated by implantation in an animal fracture model.The results showed that the novel bone plate was effective in fracture fixation,without breakage.Both X-ray and microcomputed tomography analysis showed indirect healing by both pTa trabecular bone metal plates and titanium(Ti)plates;however,elastic fixation and obvious callus formation were observed after fixation with pTa trabecular bone metal plates,indicating better bone repair.Histology showed that pTa promoted the formation of new bone and integrated well with the host bone.Therefore,this novel pTa trabecular bone metal plate has good prospects for application in treating fractures.

关 键 词：FRACTURE trabecular bone metal bone plate bone repair OSSEOINTEGRATION 

分 类 号：R318.08[医药卫生—生物医学工程]