Electrospun naringin-loaded microsphere/sucrose acetate isobutyrate system promotes macrophage polarization toward M2 and facilitates osteoporotic bone defect repair  

作　　者：Jihong Li Jinlin Song Di Meng Yin Yi Ting Zhang Yu Shu Xiaohong Wu 

机构地区：[1]Stomatological Hospital of Chongqing Medical University,No.426 Songshibei Road,Yubei District,Chongqing 401147,China [2]Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences,Chongqing 401147,China [3]Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education,Chongqing 401147,China

出　　处：《Regenerative Biomaterials》2023年第1期470-485,共16页再生生物材料（英文版）

基　　金：support from the National Natural Science Foundation of China(No.81970914).

摘　　要：Repairing osteoporotic bone defects is still a major clinical challenge.Recent studies have revealed that immune response is also essential in osteogenesis.The intrinsic inflammatory response of the host,especially the M1/M2 polarization status and inflammatory secretory function of macrophages,can directly affect osteogenic differentiation.Therefore,in this study,an electrospun naringin-loaded microspheres/sucrose acetate isobutyrate(Ng-m-SAIB)system was constructed to investigate its effect on the polarization of macrophage and osteoporotic bone defects.The results of both in vitro and in vivo experiments showed that Ng-m-SAIB had good biocompatibility and could promote the polarization of macrophage toward M2,thereby forming a favorable microenvironment for osteogenesis.The animal experiments also showed that Ng-m-SAIB could promote the osteogenesis of critical size defects in the skull of the osteoporotic model mouse(the senescence-accelerated mouse-strain P6).Together,these results collectively suggested that Ng-m-SAIB might be a promising biomaterial to treat osteoporotic bone defects with favorable osteo-immunomodulatory effects.

关 键 词：electrospun microspheres macrophage polarization Ng-m-SAIB osteoporotic bone defects 

分 类 号：R318[医药卫生—生物医学工程]