Strategies of strengthening mechanical properties in the osteoinductive calcium phosphate bioceramics  

作　　者：Qipeng Li Cong Feng Quanle Cao Wei Wang Zihan Ma Yonghao Wu Tinghan He Yangtian Jing Wenxuan Tan Tongxiao Liao Jie Xing Xiangfeng Li Ye Wang Yumei Xiao Xiangdong Zhu Xingdong Zhang 

机构地区：[1]College of Chemical Engineering,Sichuan University,Chengdu 610065,China [2]National Engineering Research Center for Biomaterials,College of Biomedical Engineering,Sichuan University,Chengdu 610065,China [3]College of Materials Science and Engineering,Sichuan University,Chengdu 610064,China

出　　处：《Regenerative Biomaterials》2023年第1期561-573,共13页再生生物材料（英文版）

基　　金：supported by the National Key Research and Development Program of China(2021YFB3802100,2021YFB3802105);Major Project of Sichuan Science and Technology Department(2022ZDZX0029);the International Science and Technology Innovation Cooperation Project of Sichuan Province(2021YFH0131);National Natural Science Foundation of China(52002256);the Science and Technology Cooperation Program of Sichuan University and Panzhihua City(2021);Sichuan University‘Zero to one’Innovation Research Project(0082604151276).

摘　　要：Calcium phosphate(CaP)bioceramics are widely applied in the bone repairing field attributing to their excellent biological properties,especially osteoinductivity.However,their applications in load-bearing or segmental bone defects are severely restricted by the poor mechanical properties.It is generally considered that it is challenging to improve mechanical and biological properties of CaP bioceramics simultaneously.Up to now,various strategies have been developed to enhance mechanical strengths of CaP ceramics,the achievements in recent researches need to be urgently summarized.In this review,the effective and current means of enhancing mechanical properties of CaP ceramics were comprehensively summarized from the perspectives of fine-grain strengthening,second phase strengthening,and sintering process optimization.What’s more,the further improvement of mechanical properties for CaP ceramics was prospectively proposed including heat treatment and biomimetic.Therefore,this review put forward the direction about how to compatibly improve mechanical properties of CaP ceramics,which can provide data and ideas for expanding the range of their clinical applications.

关 键 词：CaP ceramics strategy mechanical property OSTEOINDUCTIVITY enhancement 

分 类 号：R318.08[医药卫生—生物医学工程]