Advances in osseointegration of biomimetic mineralized collagen and inorganic metal elements of natural bone for bone repair  

作　　者：Wenbo Zhu Chao Li Mengxuan Yao Xiumei Wang Juan Wang Wei Zhang Wei Chen Hongzhi Lv 

机构地区：[1]Department of Orthopaedic Surgery,The Third Hospital of Hebei Medical University,Shijiazhuang 050051,P.R.China [2]Key Laboratory of Biomechanics of Hebei Province,Orthopaedic Research Institution of Hebei Province,Shijiazhuang 050051,P.R.China [3]NHC Key Laboratory of Intelligent Orthopaedic Equipment,The Third Hospital of Hebei Medical University,Shijiazhuang 050051,P.R.China [4]State Key Laboratory of New Ceramics and Fine Processing,School of Materials Science and Engineering,Tsinghua University,Beijing 100084,P.R.China [5]Department of Pathology,Hebei Key Laboratory of Nephrology,Center of Metabolic Diseases and Cancer Research,Hebei Medical University,Shijiazhuang 050017,P.R.China

出　　处：《Regenerative Biomaterials》2023年第1期808-829,共22页再生生物材料（英文版）

基　　金：supported by the National Natural Science Foundation of China(grant no.82102584);the National Key R&D Program of China(grant no.2020YFC1107601).

摘　　要：At this stage,bone defects caused by trauma,infection,tumor,or congenital diseases are generally filled with autologous bone or allogeneic bone transplantation,but this treatment method has limited sources,potential disease transmission and other problems.Ideal bone-graft materials remain continuously explored,and bone defect reconstruction remains a significant challenge.Mineralized collagen prepared by bionic mineralization combining organic polymer collagen with inorganic mineral calcium phosphate can effectively imitate the composition and hierarchical structure of natural bone and has good application value in bone repair materials.Magnesium,strontium,zinc and other inorganic components not only can activate relevant signaling pathways to induce differentiation of osteogenic precursor cells but also stimulate other core biological processes of bone tissue growth and play an important role in natural bone growth,and bone repair and reconstruction.This study reviewed the advances in hydroxyapatite/collagen composite scaffolds and osseointegration with natural bone inorganic components,such as magnesium,strontium and zinc.

关 键 词：mineralized collagen bone defect reconstruction inorganic metal elements clinical applications 

分 类 号：R318[医药卫生—生物医学工程]