Bioactive nanoglass regulating the myogenic differentiation and skeletal muscle regeneration  

作　　者：Dagogo Dorothy Winston Ting Li Bo Lei 

机构地区：[1]Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,College of Stomatology,Frontier Institute of Science and Technology,Xi’an Jiaotong University,Xi’an 710000,China [2]Xi’an Jiaotong University,Xi’an 710000,China [3]State-Key Laboratory for Mechanical Behavior of Materials,Xi’an Jiaotong University,Xi’an 710054,China

出　　处：《Regenerative Biomaterials》2023年第1期1202-1211,共10页再生生物材料（英文版）

基　　金：supported by the Special Support Program for High Level Talents of Shaanxi Province of China(grant No.TZ0278);the key R&D plan of Shaanxi Province of China(grant No.2021GXLH-Z-052);the Instrument Analysis Center of Xi’an Jiaotong University(for TEM and BET measurements);State Key Laboratory for Manufacturing Systems Engineering of China(grant No.sklms2021006);Young Talent Support Plan of Xi’an Jiaotong University of China(grant No.QY6J003);the key Project of Jiangxi Natural Science Foundation(No.2020ACBL214008);Jiangxi Provincial Natural Science Foundation(No.20224BAB204020).

摘　　要：Bioactive glass nanoparticles(BGNs)are widely used in the field of biomedicine,including drug delivery,gene therapy,tumor therapy,bioimaging,molecular markers and tissue engineering.Researchers are interested in using BGNs in bone,heart and skin regeneration.However,there is inadequate information on skeletal muscle tissue engineering,limited information on the biological effects of BGNs on myoblasts,and the role of bioactive glass composite materials on myogenic differentiation is unknown.Herein,we report the effects of BGNs with different compositions(60Si-BGN,80Si-BGN,100Si-BGN)on the myogenic differentiation in C2C12 cells and in vivo skeletal tissue regeneration.The results showed that 80Si-BGN could efficiently promote the myogenic differentiation of C1C12 cells,including the myotube formation and myogenic gene expression.The in vivo experiment in a rat skeletal muscle defect model also confirmed that 80Si-BGN could significantly improve the complete regeneration of skeletal muscle tissue during 4 weeks implantation.This work firstly demonstrated evidence that BGN could be the bioactive material in enhancing skeletal muscle regeneration.

关 键 词：bioactive materials bioactive ceramic bioactive glass nanoparticles skeletal tissue engineering 

分 类 号：R318[医药卫生—生物医学工程]