Biomimetic,biodegradable and osteoinductive treated dentin matrix/α-calcium sulphate hemihydrate composite material for bone tissue engineering  

作　　者：Runying Guo Rui Zhang Sirui Liu Yanyu Yang Wenhang Dong Meiyue Wang Hongyan Mi Mengzhe Liu Jingjing Sun Xue Zhang Yimeng Su Yiming Liu Di Huang Rui Li 

机构地区：[1]Department of Stomatology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,PR China [2]Department of Stomatology,The First Affiliated Hospital of Nanchang University,Nanchang 330000,PR China [3]Oral and Maxillofacial Department,Zhengzhou Stomatology Hospital,Zhengzhou 450000,PR China [4]College of Materials Science and Engineering,Zhengzhou University,Zhengzhou 450000,PR China [5]Research Center for Nano-biomaterials and Regenerative Medicine,College of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,PR China

出　　处：《Regenerative Biomaterials》2023年第1期1222-1232,共11页再生生物材料（英文版）

基　　金：the National Natural Science Foundation of China(grant numbers 31670994,U1904145 and 81901039);Nature Science Foundation of Henan Province(grant numbers 182300410340,222300420569);Henan Medical Science and Technology Research Project(grant number SBGJ202002073,SBGJ202002075);Science and Technology Department of Science and Technology Research(grant number 182102310456);Henan Province Middle-Aged And Young Health Science and Technology Innovation Leader Training Project(grant number YXKC2021014);Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University(grant number QNCXTD2023021);Union project of Medical and Technology Research Program of Henan Province(grant number LHGJ20190191).

摘　　要：It is still a huge challenge for bone regenerative biomaterial to balance its mechanical,biological and biodegradable properties.In the present study,a new composite material including treated dentin matrix(TDM)andα-calcium sulphate hemihydrate(α-CSH)was prepared.The optimal composition ratio between TDM andα-CSH was explored.The results indicate that both components were physically mixed and structurally stable.Its compressive strength reaches up to 5.027±0.035 MPa for 50%TDM/α-CSH group,similar to human cancellous bone tissues.Biological experiments results show that TDM/α-CSH composite exhibits excellent biocompatibility and the expression of osteogenic related genes and proteins(ALP,RUNX2,OPN)is significantly increased.In vivo experiments suggest that the addition of TDM for each group(10%,30%,50%)effectively promotes cell proliferation and osteomalacia.In addition,50%of the TDM/α-CSH combination displays optimal osteoconductivity.The novel TDM/α-CSH composite is a good candidate for certain applications in bone tissue engineering.

关 键 词：bone defect treated dentin matrix α-calcium sulphate hemihydrate osteogenesis 

分 类 号：R318.08[医药卫生—生物医学工程]