Photothermal effective CeO_(2)NPs combined in thermosensitive hydrogels with enhanced antibacterial,antioxidant and vascularization performance to accelerate infected diabetic wound healing  

作　　者：Zexiang Zheng Xing Yang Min Fang Jinhuan Tian Shuyun Zhang Lu Lu Changren Zhou Changpeng Xu Yong Qi Lihua Li 

机构地区：[1]College of Chemistry and Materials Science,Engineering Research Center of Artificial Organs and Materials,Jinan University,Guangzhou 511486,China [2]Guangdong Second Provincial General Hospital,Postdoctoral Research Station of Basic Medicine,School of Medicine,Jinan University,Guangdong 510632,PR China [3]Department of Orthopaedics,Guangdong Second Provincial General Hospital,Faculty of Medical Science,Jinan University,Guangzhou 510317,China

出　　处：《Regenerative Biomaterials》2023年第1期1372-1387,共16页再生生物材料（英文版）

基　　金：supported by the National Key Research and Development Project(grant no.2019YFD0901905).

摘　　要：Chronic diabetic wound healing remains a formidable challenge due to susceptibility to bacterial infection,excessive oxidative stress,and poor angiogenesis.To address these issues,a sodium alginate(SA)based photothermal hydrogel dressing with multifunction was fabricated to facilitate wound treatment.Ceria nanoparticles(CeO_(2)NPs)was synthesized,and their antibacterial performance by near-infrared light triggered photothermal effects was first studied and verified in this work.In addition,to release CeO_(2)NPs to achieve antioxidation and pro-vascularization,thermosensitive gelatin(Gel)was utilized to embed the nanoparticles in advance and then composited in SA hydrogel networks.SA network was finally strengthened by acid soaking to form partially crystalline regions to act as natural crosslinkers.Results showed that the Gel/SA/CeO_(2)hydrogel displayed temperature-responsive release of CeO_(2)NPs,significant antibacterial and antioxidative activity,as well as the ability to remove without injury and promote infected diabetic wound healing with low cytotoxicity,according to antibacterial investigations,cell studies,and in vivo animal studies.This research offers not only a successful method for quickening the healing of diabetic wounds but also a fresh approach to the general use of CeO_(2)NPs.

关 键 词：photothermal hydrogel sodium alginate cerium dioxide nanoparticle GELATIN infected diabetic wound healing 

分 类 号：TQ427.26[化学工程]