Mesoporous polydopamine delivery system for intelligent drug release and photothermal-enhanced chemodynamic therapy using MnO_(2) as gatekeeper  

作　　者：Zhaoyang Wang Zekai Li Yuehua Shi Leyong Zeng 

机构地区：[1]Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education,Chemical Biology Key Laboratory of Hebei Province,State Key Laboratory of New Pharmaceutical Preparations and Excipients,College of Chemistry and Materials Science,Hebei University,Baoding 071002,P.R.China

出　　处：《Regenerative Biomaterials》2023年第1期1566-1576,共11页再生生物材料（英文版）

基　　金：supported by the National Natural Science Foundation of China(U20A20254,U1732127 and 51772074);Natural Science Foundation of Hebei Province(C2020201025);Central Government Guided Local Science and Technology Development Project of Hebei Province(226Z1302G);Natural Science Interdisciplinary Research Program of Hebei University(DXK202002);Research Innovation Team of College of Chemistry and Environmental Science of Hebei University(hxkytd-py2103).

摘　　要：The non-specific leakage of drugs from nanocarriers seriously weakened the safety and efficacy of chemotherapy,and it was very critical of constructing tumor microenvironment(TME)-responsive delivery nanocarriers,achieving the modulation release of drugs.Herein,using manganese dioxide(MnO_(2))as gatekeeper,an intelligent nanoplatform based on mesoporous polydopamine(MPDA)was developed to deliver doxorubicin(DOX),by which the DOX release was precisely controlled,and simultaneously the photothermal therapy(PTT)and chemodynamic therapy(CDT)were realized.In normal physiological environment,the stable MnO_(2)shell effectively avoided the leakage of DOX.However,in TME,the overexpressed glutathione(GSH)degraded MnO_(2)shell,which caused the DOX release.Moreover,the photothermal effect of MPDA and the Fenton-like reaction of the generated Mn^(2+)further accelerated the cell death.Thus,the developed MPDA-DOX@MnO_(2)nanoplatform can intelligently modulate the release of DOX,and the combined CDT/PTT/chemotherapy possessed high-safety and high-efficacy against tumors.

关 键 词：mesoporous polydopamine MnO_(2)gatekeeper chemotherapy photothermal therapy chemodynamic therapy 

分 类 号：R318[医药卫生—生物医学工程]