Electroconductivity,a regenerative engineering approach to reverse rotator cuff muscle degeneration  

作　　者：Nikoo Saveh-Shemshaki Mohammed A.Barajaa Takayoshi Otsuka Elnaz S.Mirdamadi Lakshmi S.Nair Cato T.Laurencin 

机构地区：[1]The Cato T.Laurencin Institute for Regenerative Engineering,University of Connecticut,Farmington,CT 06030,USA [2]Department of Biomedical Engineering,University of Connecticut,Storrs,CT 06269,USA [3]Department of Biomedical Engineering,Imam Abdulrahman Bin Faisal University,Dammam 31451,Saudi Arabia [4]Department of Orthopedic Surgery,University of Connecticut Health Center,Farmington,CT 06030,USA [5]Department of Materials Science and Engineering,University of Connecticut,Storrs,CT 06269,USA [6]Department of Chemical&Biomolecular Engineering,University of Connecticut,Storrs,CT 06269,USA

出　　处：《Regenerative Biomaterials》2023年第1期1693-1712,共20页再生生物材料（英文版）

基　　金：funded by DHHS/NIH/NIAMS entitled,Regenerative Engineering of Complex Musculoskeletal Tissue and Joints(Grant No.:DP1AR068147 and NSF/EFRI Grant No:1332329);funded by Imam Abdulrahman Bin Faisal University,Dammam 34212,Saudi Arabia.

摘　　要：Inhalation-administrated drugs remain an interesting possibility of addressing pulmonary diseases.Direct drug delivery to the lungs allows one to obtain high concentration in the site of action with limited systemic distribution,leading to a more effective therapy with reduced required doses and side effects.On the other hand,there are several difficulties in obtaining a formulation that would meet all the criteria related to physicochemical,aerodynamic and biological properties,which is the reason why only very few of the investigated systems can reach the clinical trial phase and proceed to everyday use as a result.Therefore,we focused on powders consisting of polysaccharides,lipids,proteins or natural and synthetic polymers in the form of microparticles that are delivered by inhalation to the lungs as drug carriers.We summarized the most common trends in research today to provide the best dry powders in the right fraction for inhalation that would be able to release the drug before being removed by natural mechanisms.This review article addresses the most common manufacturing methods with novel modifications,pros and cons of different materials,drug loading capacities with release profiles,and biological properties such as cytocompatibility,bactericidal or anticancer properties.

关 键 词：pulmonary therapies drug delivery systems to lungs MICROPARTICLES INHALERS dry powder inhalers 

分 类 号：R318[医药卫生—生物医学工程]