CD4^(+)T细胞亚群在皮肌炎发病机制中的研究进展  

Research progress on CD4^(+)T cell subsets in the pathogenesis of dermatomyositis

作　　者：谢瑜欢 苏芮 刘潞 姜蕾 王彩虹[1] XIE Yuhuan;SU Rui;LIU Lu;JIANG Lei;WANG Caihong(Department of Rheumatology,The Second Hospital of Shanxi Medical University,Taiyuan,Shanxi 030001,China)

机构地区：[1]山西医科大学第二医院风湿免疫科,山西太原030001

出　　处：《安徽医药》2024年第10期1926-1930,共5页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金项目(81971543)。

摘　　要：目的探讨皮肌炎(DM)的免疫学发病机制,特别关注CD4^(+)T细胞亚群在其发病过程中的作用。方法从免疫失衡的角度,通过分析近10年来的文献,深入探讨了DM与CD4^(+)T细胞亚群的关联,全面梳理了细胞因子及相关信号分子等方面的信息。结果主导免疫反应的CD4^(+)T细胞亚群,在DM的发病过程中有显著影响。其中,辅助性T细胞1型(Th1)与Th2和Th17与调节性T细胞(Tregs)比值的不平衡在DM的病理过程中起着核心作用。新发现的CD4^(+)T细胞亚群,Tph细胞(PD-1hiCXCR5−CD4^(+))可能也参与DM的发病过程。结论CD4^(+)T细胞因子的异常表达及其网络失衡参与了DM的免疫学发病机制,为治疗DM提供了新的视角。Objective To investigate the immunological pathogenesis of dermatomyositis(DM),with a particular focus on the role of CD4^(+)T cell subsets in its development.Methods From the perspective of immune imbalance,we deeply explored the association between DM and CD4^(+)T cell subsets by analyzing literature from the past decade.We comprehensively reviewed information regarding cytokines and related signaling molecules.Results CD4^(+)T cell subsets that dominated the immune response had a significant impact on the pathogenesis of DM.Among them,the imbalance in the ratio of Th1 to Th2 and Th17 to regulatory T cells(Tregs)played a central role in the pathology of DM.Additionally,newly identified CD4^(+)T cell subsets,specifically Tph cells(PD-1hi CXCR5−CD4^(+)),might also be involved in the pathogenesis of DM.Conclusion The abnormal expression of CD4^(+)T cell cytokines and the imbalance of their network are involved in the immunological pathogenesis of DM,providing new perspectives for the treatment of DM.

关 键 词：皮肌炎 CD4^(+)T细胞亚群 免疫平衡 辅助性T细胞1型/辅助性T细胞2型 辅助性T细胞17型/调节性T细胞 综述 

分 类 号：R593.26[医药卫生—内科学]