代谢综合征对中老年男性下尿路症状的影响  

Effects of metabolic syndrome on lower urinary tract symptoms in middle-aged and older men

作　　者：詹皓程 唐钊[1] 章松巍 王富成 王康宇 刘岩 张会清[1] 文建国[2] ZHAN Haocheng;TANG Zhao;ZHANG Songwei;WANG Fucheng;WANG Kangyu;LIU Yan;ZHANG Huiqing;WEN Jianguo(Department of Urology,The First Affiliated Hospital of Xinxiang Medical College,Xinxiang Key Laboratory of Diagnosis and Treatment of Lower Urinary Tract Obstruction,Weihui,He´nan 453100,China;Department of Urology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,He´nan 450052,China)

机构地区：[1]新乡医学院第一附属医院泌尿外科、新乡市下尿路梗阻诊疗重点实验室,河南卫辉453100 [2]郑州大学第一附属医院泌尿外科,河南郑州450052

出　　处：《安徽医药》2024年第10期1967-1973,共7页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金项目(U1904208);河南省医学科技攻关计划项目(LHGJ20220606);新乡市下尿路梗阻诊疗重点实验室项目(新科〔2023〕2号)。

摘　　要：目的探讨代谢综合征与中老年男性下尿路症状之间的联系。方法选取2021年12月至2023年3月新乡医学院第一附属医院因出现下尿路症状收治住院的432例中老年男性病人作为研究对象。分为五组:代谢综合征组(同时具有高血压、糖尿病和肥胖三项诊断,39例)、三无人群组(不具有高血压、糖尿病、肥胖任何一项诊断,55例)、高血压组(只具有高血压一项诊断,105例)、糖尿病组(只具有糖尿病一项诊断,83例)、肥胖组(只具有肥胖一项诊断,150例)。收集所有病人的基本信息,包括年龄、体质量、身高、肌酐值、高血压及糖尿病诊治史等临床资料,进行国际前列腺症状评分(international prostate symptom score,IPSS)和健康相关生活质量(health-related quality of life,HRQOL)问卷调查,最后对病人进行自由尿流率检查及膀胱残余尿量(residual urine volume,RUV)测定。结果代谢综合征组的IPSS总评分、HRQOL评分、RUV显著高于三无人群组(P<0.05),最大尿流率[13.6(9.6,17.6)mL/s比17.6(13.6,22.2)mL/s]、平均尿流率[6.8(4.9,8.7)mL/s比8.6(6.7,11.3)mL/s]显著低于三无人群组(P<0.05),两组之间的年龄和肌酐值差异无统计学意义。高血压组的IPSS总评分、HRQOL评分、RUV值显著高于三无人群组(P<0.05),最大尿流率、平均尿流率显著低于三无人群组(P<0.05),两组之间的年龄和肌酐值差异无统计学意义。糖尿病组的IPSS总评分、HRQOL评分、肌酐值显著高于三无人群组(P<0.05),最大尿流率、平均尿流率显著低于三无人群组(P<0.05),两组之间的年龄和RUV差异无统计学意义。肥胖组的IPSS总评分、HRQOL评分、肌酐值显著高于三无人群组(P<0.05),两组之间的年龄、最大尿流率、平均尿流率和RUV差异无统计学意义。结论代谢综合征明显加重中老年男性的下尿路症状,并且影响其生活质量。代谢异常中的高血压、糖尿病、肥胖可能是下尿路症状的危险因素�Objective To investigate the association between metabolic syndrome and lower urinary tract symptoms in middle-aged and older men.Methods A total of 432 middle-aged and elderly male patients who were admitted to the First Affiliated Hospital of Xinxiang Medical University due to lower urinary tract symptoms from December 2021 to March 2023 were selected as the research subjects.The 432 patients were assigned into the following five groups:the metabolic syndrome group(with all three diagnoses of hypertension,diabetes and obesity,39 cases),the non-triple-negative group(without any of the diagnoses of hypertension,diabetes and obesity,55 cases),the hypertension group(with only the diagnosis of hypertension,105 cases),the diabetes group(with only the diagnosis of diabetes,83 cases),and the obesity group(with only the diagnosis of obesity,150 cases).The basic information of all patients,including age,body mass,height,creatinine value,history of diagnosis and treatment of hypertension and diabetes and other clinical data were collected.The International Prostate Symptom Score(IPSS)and Health-related Quality of Life(HRQOL)questionnaires were conducted.Finally,free uroflowmetry and bladder residual urine volume(residual urine volume,RUV)measurement were performed on the patients.Results The total IPSS score,HRQOL score,and RUV of the metabolic syndrome group were significantly higher than those of the non-triple-negative group(P<0.05),and the maximum urine flow rate[13.6(9.6,17.6)mL/s vs.17.6(13.6,22.2)mL/s]and average urine flow rate[6.8(4.9,8.7)mL/s vs.8.6(6.7,11.3)mL/s]were significantly lower than those of the non-triple-negative group(P<0.05).There was no statistically significant difference in age and creatinine value between the two groups.The total IPSS score,HRQOL score,and RUV value of the hypertension group were significantly higher than those of the non-triple-negative group(P<0.05),and the maximum urine flow rate and average urine flow rate were significantly lower than those of the non-triple-negative group

关 键 词：代谢综合征 下尿路症状 国际前列腺症状评分 尿流率 中老年男性 

分 类 号：R589[医药卫生—内分泌] R691[医药卫生—内科学]