白细胞介素-34、脂肪细胞型脂肪酸结合蛋白4与小儿支气管哮喘的关系  

The relationship between interleukin-34,adipocyte fatty acid binding protein 4,and pediatric bronchial asthma

作　　者：管鑫蕊 李连家 王道方[1] GUAN Xinrui;LI Lianjia;WANG Daofang(Department of Pediatric Medicine,Liaocheng Second People´s Hospital,Liaocheng,Shandong 252600,China)

机构地区：[1]聊城市第二人民医院小儿内科,山东聊城252600

出　　处：《安徽医药》2024年第10期2039-2043,共5页Anhui Medical and Pharmaceutical Journal

基　　金：山东省中医药科技项目(M-2022126)。

摘　　要：目的探讨血清白细胞介素-34(IL-34)、脂肪细胞型脂肪酸结合蛋白4(FABP4)对支气管哮喘病儿病情及控制水平的评估价值。方法收集聊城市第二人民医院2020年6月至2023年1月治疗的97例支气管哮喘病儿为病例组,依据病儿病情程度分为轻度哮喘组32例、中度哮喘组41例、重度哮喘组24例,依据病儿病情控制水平分为控制组56例和未控制组41例;另选取95例体检健康儿童作为对照组,比较各组血清IL-34、FABP4水平;采用logistic回归分析支气管哮喘病儿病情控制水平的影响因素;采用受试者操作特征曲线(ROC曲线)分析血清IL-34、FABP4水平对支气管哮喘病儿病情未控制的评估价值。结果病例组血清IL-34[(25.74±7.31)ng/L比(2.46±0.73)ng/L]、FABP4[(27.82±4.10)μg/L比(11.69±3.07)ng/L]水平高于对照组(P<0.05)。重度哮喘组血清IL-34[(34.78±9.31)ng/L比(25.82±7.26)ng/L比(18.79±6.64)ng/L]、FABP4[(37.14±7.40)μg/L比(28.04±4.75)μg/L比(20.55±5.15)μg/L]水平高于中度哮喘组和轻度哮喘组,中度哮喘组血清IL-34、FABP4水平高于轻度哮喘组(P<0.05)。未控制组血清IL-34、FABP4水平及治疗依从性差、有呼吸道感染的病儿比例高于控制组(P<0.05)。IL-34、FABP4是支气管哮喘病儿病情未控制的独立危险因素(P<0.05)。血清IL-34、FABP4水平单独及联合评估支气管哮喘病儿病情未控制的AUC分别为0.78、0.85、0.93。结论血清IL-34、FABP4水平与支气管哮喘病儿病情程度密切相关,可较好地评估病情控制水平。Objective To explore the evaluation value of serum interleukin-34(IL-34)and adipocyte fatty acid binding protein 4(FABP4)for the condition and control level of bronchial asthma in children.Methods A total of 97 children with bronchial asthma treated in Liaocheng Second People's Hospital from June 2020 to January 2023 were collected as a case group,according to the severity of the patient's condition,they were grouped into a mild asthma group of 32 cases,a moderate asthma group of 41 cases,and a severe asthma group of 24 cases,according to the level of disease control,the children were grouped into a control group of 56 cases and an uncontrolled group of 41 cases;another 95 healthy children undergoing physical examination were collected as the control group,the levels of IL-34 and FABP4 in serum of each group were compared;Logistic regression analysis was applied to analyze influence factors on the level of disease control in children with bronchial asthma;receiver operating characteristic(ROC)curve was applied to analyze the evaluation value of serum IL-34 and FABP4 levels for uncontrolled condition in children with bronchial asthma.Results The serum levels of IL-34[(25.74±7.31)ng/L vs.(2.46±0.73)ng/L]and FABP4[(27.82±4.10)μg/L vs.(11.69±3.07)ng/L]in the case group were higher than those in the control group(P<0.05).The serum levels of IL-34[(34.78±9.31)ng/L vs.(25.82±7.26)ng/L vs.(18.79±6.64)ng/L]and FABP4[(37.14±7.40)μg/L vs.(28.04±4.75)μg/L vs.(20.55±5.15)μg/L]in the severe asthma group were higher than those in the moderate and mild asthma groups,while the serum levels of IL-34 and FABP4 in the moderate asthma group were higher than those in the mild asthma group(P<0.05).The levels of IL-34 and FABP4 in the serum,and the proportions of children with poor treatment compliance and respiratory infections in the uncontrolled group were higher than those in the control group(P<0.05).IL-34 and FABP4 were independent risk factors for uncontrolled condition in children with bronchial asthma(P<0.05).The

关 键 词：支气管哮喘 白细胞介素-34 脂肪细胞型脂肪酸结合蛋白4 控制水平 儿童 

分 类 号：R725.6[医药卫生—儿科]