神曲消食口服液联合枸橼酸莫沙必利对功能性消化不良患儿的疗效  

Curative effect of Shenqu Xiaoshi oral liquid combined with Mosapride citrate on children with functional dyspepsia

作　　者：唐红强[1] 周巍玲 Tang Hongqiang;Zhou Weiling(Pediatric Digestive Nutrition Department,Baoji Maternal and Child Health Hospital,Baoji 721000,China;Pediatric Emergency Intensive Care Department,Baoji Maternal and Child Health Hospital,Baoji 721000,China)

机构地区：[1]宝鸡市妇幼保健院儿童消化营养科,宝鸡721000 [2]宝鸡市妇幼保健院儿童急诊重症科,宝鸡721000

出　　处：《国际医药卫生导报》2024年第18期3111-3115,共5页International Medicine and Health Guidance News

基　　金：陕西省科技计划发展项目(20202046)。

摘　　要：目的评估神曲消食口服液联合枸橼酸莫沙必利改善功能性消化不良患儿胃动力指标及缓解其症状的效果。方法本研究为随机对照试验,选取在2021年5月至2023年5月期间宝鸡市妇幼保健院收治的150例功能性消化不良患儿作为研究对象,通过随机数字表法将患儿分为对照组(75例)和观察组(75例)。对照组男41例,女34例,年龄(6.89±1.13)岁,病程(5.76±1.08)个月;观察组男44例,女31例,年龄(7.10±1.22)岁,病程(5.85±1.13)个月。对照组患儿予以枸橼酸莫沙必利治疗(7岁以下的儿童,每次2.5 mg,每天3次;7岁及以上的儿童,每次5.0 mg,每天3次),观察组患儿予以神曲消食口服液(5岁以下的儿童,每次5 ml,每天3次;5岁及以上的儿童,每次10 ml,每天3次)联合枸橼酸莫沙必利治疗,持续治疗两周。比较两组患儿治疗前及治疗两周后胃动力指标[胃窦收缩频率(ACF)、胃窦收缩幅度(ACA)、运动指数(MI)]、肠道菌群(肠杆菌、肠球菌、双歧杆菌、乳杆菌)、症状积分及不良反应(口干、腹泻、头晕、乏力、呕吐)。采用t检验、χ^(2)检验。结果治疗后,观察组患儿ACF、ACA、MI水平分别为(4.06±0.67)次/min、(52.43±5.24)mm、(2.18±0.20),均高于对照组(1.94±0.43)次/min、(49.54±4.95)mm、(1.82±0.17),差异均有统计学意义(均P<0.05);治疗后,观察组患儿双歧杆菌、乳杆菌数量分别为(9.78±1.23)CFU/g、(9.79±1.38)CFU/g,高于对照组(7.39±1.71)CFU/g、(6.89±1.44)CFU/g,肠杆菌、肠球菌数量分别为(4.41±0.43)CFU/g、(3.85±0.37)CFU/g,低于对照组(7.33±1.22)CFU/g、(6.52±0.74)CFU/g,差异均有统计学意义(均P<0.05);治疗后,观察组患儿主次症各维度积分均低于对照组,差异均有统计学意义(均P<0.05);观察组患儿的不良反应总发生率17.33%(13/75)高于对照组10.67%(8/75),但差异无统计学意义(χ^(2)=1.384,P=0.239)。结论对功能性消化不良患儿给予神曲消食口服液与枸橼酸莫沙必利联合治疗,能�Objective To evaluate the efficacy of Shenqu Xiaoshi oral liquid combined with Mosapride citrate in improving gastric motility indicators and alleviating symptoms in children with functional dyspepsia.Methods This study was a randomized controlled trial.A total of 150 children with functional dyspepsia admitted to Baoji Maternal and Child Health Hospital from May 2021 to May 2023 were selected as the study objects,and were divided into a control group(75 cases)and an observation group(75 cases)by the random number table method.In the control group,41 boys and 34 girls were(6.89±1.13)years old and the course of disease was(5.76±1.08)months.In the observation group,44 boys and 31 girls were(7.10±1.22)years old and the course of disease was(5.85±1.13)months.The control group was treated with Mosapride citrate(for children under 7 years old,2.5 mg each time,3 times a day;for children≥7 years old,5.0 mg each time,3 times a day),and the observation group was treated with Shenqu Xiaoshi oral liquid(for children under 5 years old,5 ml each time,3 times a day;for children≥5 years old,10 ml each time,3 times a day)combined with Mosapride citrate for 2 weeks.The gastric motility indicators[antral contraction frequency(ACF),antral contraction amplitude(ACA),and motility index(MI)],intestinal flora(Escherichia coli,Enterococcus,Bifidobacterium,and Lactobacillus),symptom scores,and adverse reactions(dry mouth,diarrhea,dizziness,fatigue,and vomiting)were compared between the two groups before and two weeks after treatment.t test andχ^(2)test were used.Results After treatment,the ACF,ACA and MI levels in the observation group were(4.06±0.67)times/min,(52.43±5.24)mm,and(2.18±0.20),which were higher than those in the control group[(1.94±0.43)times/min,(49.54±4.95)mm,and(1.82±0.17)],with statistically significant differences(all P<0.05).After treatment,the counts of Bifidobacterium and Lactobacillus in the observation group were(9.78±1.23)CFU/g and(9.79±1.38)CFU/g,which were higher than those in the control group[(

关 键 词：功能性消化不良 神曲消食口服液 枸橼酸莫沙必利 胃动力指标 症状积分 儿童 

分 类 号：R725.7[医药卫生—儿科]