脂肪间充质干细胞外泌体源非编码RNA在创面愈合中的作用  

Role of exosomal noncoding RNA from adipose-derived mesenchymal stem cells in wound healing

作　　者：刘丽桦 刘德伍[1] LIU Lihua;LIU Dewu(Medical Center of Burn Plastic and Wound Repair,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi,China;Huankui Academy,Nanchang University,Nanchang 330006,Jiangxi,China)

机构地区：[1]南昌大学第一附属医院烧伤整形与创面修复医学中心,江西南昌330006 [2]南昌大学焕奎书院,江西南昌330006

出　　处：《中国临床药理学与治疗学》2024年第9期1049-1056,共8页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金(81460293)。

摘　　要：外泌体(exosomes,Exos)是脂肪间充质干细胞(adipose-derived mesenchymal stem cells,ADSCs)主动分泌的纳米大小的膜性囊泡,通过自身含有的生物活性分子如长链非编码RNA(lncRNA)、微小RNA(miRNA)和环状RNA(circRNA)等非编码RNA(ncRNA)进入相应的靶细胞,参与细胞间通讯。脂肪间充质干细胞外泌体源非编码RNA(ADSC-Exo-ncRNA)可调控机体免疫和炎症反应、血管生成,加速皮肤细胞增殖和上皮化,调节胶原重塑,从而增强创面修复能力。因此,ADSC-ExoncRNA在创面修复过程中发挥重要作用,有望成为创面修复治疗的新策略。本文对近年来ADSCExo-ncRNA在创面愈合中的作用及其应用前景进行综述。Exosomes(Exos)are nano-sized membrane vesicles actively secreted by adipose-derived mesenchymal stem cells(ADSCs),carrying bioactive molecules such as long non-coding RNA(lncRNA),microRNA(miRNA),and circular RNA(circRNA),which are non-coding RNAs(ncRNA)that enter into the corresponding target cells and participate in intercellular communication.ADSC-Exo-ncRNA can regulate the immune and inflammatory response,angiogenesis,accelerate skin cell proliferation and epithelialization,and regulate collagen remodeling,thereby enhancing wound repair ability.Therefore,ADSC-Exo-ncRNA exerts an significant role in the process of wound repair and provides a promising strategy for treatment.In this paper,we review the role of ADSC-Exo-ncRNA in wound healing and its application prospects in recent year.

关 键 词：脂肪间充质干细胞 外泌体 非编码RNA 创面愈合 

分 类 号：R64[医药卫生—外科学]