烟酰胺腺嘌呤二核苷酸磷酸氧化酶2对老年颅脑损伤患者的影响  

Effect of serum NOX2 level on elderly patients with traumatic brain injury

作　　者：崔茜 杨丽梅 常玉平 王晓晔 Cui Qian;Yang Limei;Chang Yuping;Wang Xiaoye(First Department of Neurology,Handan People's Hospital,Handan 056001,Hebei Province,China)

机构地区：[1]邯郸市人民医院神内一科,056001

出　　处：《中华老年心脑血管病杂志》2024年第9期1073-1078,共6页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的 探讨血清还原烟酰胺腺嘌呤二核苷酸磷酸氧化酶2(nicotinamide adenine dinucleotide phosphate reduced oxidase 2,NOX2)水平与老年颅脑损伤患者脑组织血供和预后的相关性。方法 选取2019年1月至2022年12月邯郸市人民医院神内一科收治的老年颅脑损伤患者86例作为颅脑损伤组,另选取同期年龄、性别相匹配的老年健康体检者80例作为对照组。颅脑损伤组根据入院时格拉斯哥昏迷评分(Glasgow coma score, GCS)分为轻型组22例,中型组35例和重型组29例。颅脑损伤组治疗后6个月根据格拉斯哥预后评分(Glasgow outcome score, GOS)分为预后良好组54例和预后不良组32例。比较各组血清NOX2水平和脑血流指标动态变化,分析其与预后GOS评分的相关性。结果 与对照组比较,颅脑损伤组1、3、5、7、10 d的平均血流速度(mean blood flow velocity, Vm)、局部脑血流量(region cerebral blood flow, rCBF)、局部脑血容量(region cerebral blood volume, rCBV)显著降低,血清NOX2水平显著升高(P<0.01)。不同程度颅脑损伤组1、3、5、7、10 d血清NOX2水平比较,差异有统计学意义(P<0.05,P<0.01)。颅脑损伤组1、3、5、7、10、14 d血清NOX2水平与入院时GCS评分呈负相关(r=-0.413、-0.427、-0.515、-0.592、-0.566、-0.338,P<0.01),1、3、5、7、10 d的Vm、rCBV、rCBF与GCS评分呈正相关(r=0.392、0.379、0.407、0.418、0.420,P<0.01;r=0.404、0.414、0.429、0.419、0.428,P<0.01;r=0.412、0.427、0.432、0.428、0.393,P<0.01)。颅脑损伤组1、3、5、7、10 d血清NOX2水平与Vm、rCBV、rCBF呈负相关(P<0.01)。预后不良组1、3、5、7、10、14 d血清NOX2水平显著高于预后良好组,Vm、rCBV、rCBF显著低于预后良好组(P<0.05,P<0.01)。颅脑损伤组1、3、5、7、10、14 d血清NOX2水平与治疗后6个月GOS评分呈负相关,Vm、rCBV、rCBF与GOS评分呈正相关(P<0.01)。结论 血清NOX2水平升高与老年颅脑损伤患者脑组织血供不足和预后不良密切相关,动�Objective To explore the correlation of serum level of reduced NOX2 with cerebral blood supply and prognosis in elderly patients with TBI.Methods A total of 86 elderly TBI patients admitted to our department from January 2019 to December 2022 were recruited and served as the TBI group, and another 80 age-and gender-matched elderly individuals who took physical examinees in our hospital during the same period were enrolled and served as the control group.According to the GCS score at admission, the TBI group was divided into mild, moderate and severe subgroups(22,35 and 29 cases).The patients were also assigned into good prognosis subgroup(54 cases) and poor prognosis subgroup(32 cases) based on GOS score in 6 months after treatment.The dynamic changes in serum NOX2 level and cerebral blood flow indicators among different groups and subgroups were compared, and their correlation with the prognostic GOS score was analyzed.Results The average blood flow Vm, rCBF,and rCBV of TBI patients at 1,3,5,7,and 10 d after injury were significantly reduced, and the serum NOX2 level was obviously increased when compared to the control group(P<0.01).Statistical difference was seen in serum NOX2 level among the patients with different degrees of TBI at 1,3,5,7 and 10 d after injury(P<0.05,P<0.01).The serum NOX2 level at 1,3,5,7,10 and 14 d after injury in the TBI group was negatively correlated with GCS score(r=-0.413,-0.427,-0.515,-0.592,-0.566,-0.338;P<0.01),and the Vm CBV,and rCBF values at 1,3,5,7,and 10 d after injury were positively correlated with GCS score(r=0.392,0.379,0.407,0.418,0.420,P<0.01;r=0.404,0.414,0.429,0.419,0.428,P<0.01;r=0.412,0.427,0.432,0.428,0.393,P<0.01).The serum NOX2 level at 1,3,5,7 and 10 d after injury in the TBI group was negatively correlated with Vm, rCBV and rCBF values(P<0.01).The serum NOX2 level of the patients in the poor prognosis subgroup were significantly higher than those in the good prognosis subgroup at 1,3,5,7,10,and 14 d after injury, while, the rCBV and rCBF values were obviously l

关 键 词：脑损伤 创伤性 NADPH氧化酶2 预后 数据相关性 

分 类 号：R651.15[医药卫生—外科学]