血清CCL18、sTLT-1水平与冠心病患者冠状动脉病变关系及预测价值  

Serum CCL18 and sTLT-1 levels and clinical significance in patients with coronary artery disease

作　　者：秦道铎 赵江峰[1] 杨旭明[1] 杨靖 赵飞龙[1] Qin Daoduo;Zhao Jiangfeng;Yang Xuming;Yang Jing;Zhao Feilong(Department of Cardiology,The First Affiliated Hospital of Henan University of Science and Technology,Henan Province,Luoyang 471003,China)

机构地区：[1]河南科技大学第一附属医院心血管内科,河南洛阳471003

出　　处：《疑难病杂志》2024年第9期1080-1084,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：河南省医学科技攻关计划项目(LHGJ20200568)。

摘　　要：目的探讨冠心病患者血清趋化因子配体18(CCL18)、可溶性髓样细胞触发受体样转录因子-1(sTLT-1)水平与冠状动脉病变严重程度的相关性。方法选取2022年6月—2023年6月河南科技大学第一附属医院心血管内科行经皮冠状动脉造影的冠心病患者110例为冠心病组,采用SYNTAX评分评估冠状动脉病变严重程度,将患者分为轻度亚组54例、中度亚组37例、重度亚组19例。另选取同期医院健康体检者110例为健康对照组。采用酶联免疫吸附法(ELISA)检测血清CCL18、sTLT-1表达水平;Spearman法分析血清CCL18、sTLT-1水平与冠状动脉病变严重程度的相关性;多因素Logistic回归分析冠心病患者冠状动脉病变严重程度的影响因素;受试者工作特征(ROC)曲线评估血清CCL18、sTLT-1水平对中重度冠状动脉病变的诊断价值。结果冠心病组血清CCL18、sTLT-1水平均显著高于健康对照组(t/P=7.505/<0.001,8.537/<0.001);随着冠状动脉病变程度加重,轻度亚组、中度亚组、重度亚组冠心病患者血清CCL18、sTLT-1水平依次升高(F/P=24.542/<0.001,28.067/<0.001);血清CCL18、sTLT-1水平与冠状动脉病变严重程度呈正相关(r/P=0.486/<0.001,0.391/<0.001);多因素Logistic回归分析显示,CCL18升高、sTLT-1升高是冠状动脉病变严重程度的独立危险因素[OR(95%CI)=2.376(1.169~4.830),2.695(1.494~4.862)];血清CCL18、sTLT-1水平及二者联合诊断中重度冠状动脉病变的AUC分别为0.748、0.721、0.813,二者联合的AUC大于血清CCL18、sTLT-1各自单独诊断(Z/P=2.139/0.032,2.248/0.025)。结论冠心病患者血清CCL18、sTLT-1水平均明显升高,二者与冠状动脉病变严重程度有关。Objective To investigate the correlation between serum levels of CC chemokine ligand 18(CCL18)and soluble triggering receptor expressed on myeloid cell 1(sTLT-1)in patients with coronary heart disease and the severity of coronary artery disease.Methods From June 2022 to June 2023,110 patients with coronary heart disease who underwent percutaneous coronary angiography Department of cardiology,the First Affiliated Hospital of Henan University of Science and Technology were gathered as the coronary heart disease group,the SYNTAX score was applied to assess the severity of coronary artery disease,and patients were separated into mild subgroup(54 cases),moderate subgroup(37 cases),and severe subgroup(19 cases),Another 110 cases of health checkups in hospitals in the same period were selected as the healthy control group.Enzyme linked immunosorbent assay(ELASA)was applied to detect the expression levels of serum CCL18 and sTLT-1;Spearman method was applied to analyze the correlation between serum CCL18,sTLT-1 levels and the severity of coronary artery disease;Logistic regression was applied to analyze the influencing factors of the severity of coronary artery disease;receiver operating characteristic(ROC)curve was applied to evaluate the diagnostic value of serum CCL18 and sTLT-1 levels for moderate to severe coronary artery disease.Results The serum levels of CCL18 and sTLT-1 in the coronary heart disease group were obviously higher than those in the control group(t/P=7.505/<0.001,8.537/<0.001).As the degree of coronary artery disease increased,serum CCL18 and sTLT-1 levels increased sequentially in the mild,moderate,and severe subgroups of patients with coronary artery disease(F/P=24.542/<0.001,28.067/<0.001).There was a positive correlation between serum CCL18,sTLT-1 levels and both with the severity of coronary artery lesions(r/P=0.486/<0.001,0.391/<0.001).Multifactorial Logistic regression analysis showed that elevated CCL18 and elevated sTLT-1 were independent risk factors for the severity of coronary artery lesi

关 键 词：冠心病 趋化因子配体18 可溶性髓样细胞触发受体样转录因子-1 冠状动脉病变 相关性 预测价值 

分 类 号：R541.4[医药卫生—心血管疾病]