血清IL-19、VASH-1、NLR在2型糖尿病肾病中的水平及临床意义  

The levels and clinical significance of serum IL-19,VASH-1 and NLR in type 2 diabetic nephropathy

作　　者：颜建军[1] 李利萍 胡杨 程木子 程玲 张文静 张楠 张丽莎 Yan Jianjun;Li Liping;Hu Yang;Cheng Muzi;Cheng Ling;Zhang Wenjing;Zhang Nan;Zhang Lisha(Department of Endocrinology,Handan First Hospital,Hebei Province,Handan 056002,China)

机构地区：[1]河北省邯郸市第一医院内分泌一科,056002

出　　处：《疑难病杂志》2024年第9期1090-1093,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：2022年度河北省医学科学研究课题计划(20220486)。

摘　　要：目的探讨血清白介素19(IL-19)、血管生成抑制蛋白1(VASH-1)、中性粒细胞与淋巴细胞比值(NLR)在2型糖尿病肾病(T2DN)中的水平及意义。方法选取2020年12月—2022年12月在邯郸市第一医院内分泌一科治疗的T2DN患者100例作为T2DN组,同时收集单纯2型糖尿病(T2DM)患者100例作为T2DM组,比较2组血清IL-19、VASH-1、NLR水平,并分析血清IL-19、VASH-1、NLR对T2DN的预测价值。结果T2DN组血清IL-19、VASH-1、NLR明显高于T2DM组(t/P=8.374/<0.001、8.277/<0.001、8.762/<0.001)。经二元Logistic回归分析,IL-19、VASH-1、NLR升高是发生T2DN的危险因素[OR(95%CI)=1.120(1.037~1.210)、1.006(1.001~1.012)、2.586(1.165~5.740),P<0.05]。受试者工作特征(ROC)曲线分析显示,IL-19、VASH-1、NLR及三者联合预测T2DN的曲线下面积(AUC)分别为0.807、0.799、0.822、0.854,约登指数分别为0.520、0.490、0.550、0.740,IL-19在最佳截断值对应的敏感度、特异度分别为0.940、0.580,VASH-1为0.660、0.830,NLR为0.920、0.630,三者联合为0.860、0.880。结论T2DN患者血清IL-19、VASH-1、NLR水平升高,且血清IL-19、VASH-1、NLR三者联合对T2DN具有较高的预测价值。Objective To investigate the levels and significance of serum interleukin 19(IL-19),vasohibin-1(VASH-1),neutrophil-to-lymphocyte ratio(NLR)in type 2 diabetic nephropathy(T2DN).Methods 100 patients with T2DN who were treated in our hospital from December 2020 to December 2022 were selected as the T2DN group,and 100 patients with type 2 diabetes mellitus(T2DM)alone were collected as the T2DM group.The levels of serum IL-19,VASH-1,and NLR were compared among the two groups,and the predictive value of serum IL-19,VASH-1,and NLR for DN was analyzed.Results The serum levels of IL-19,VASH-1,and NLR in the T2DN group were significantly higher than those in the T2DM group(t/P=8.347/<0.001、8.277/<0.001、8.762/<0.001).According to binary Logistic regression analysis,high IL-19,VASH-1,and NLR are risk factors for T2DN[OR(95%CI)=1.120(1.037-1.210),1.006(1.001-1.012),2.586(1.165-5.740),P<0.05].Receiver operating characteristic(ROC)curve analysis showed that,The area under the curve(AUC)of serum IL-19、VASH-1、NLR and their combined prediction of T2DN were 0.807,0.799,0.822,0.854,respectively.The Yoden indices were 0.520,0.490,0.550,0.740.The sensitivity and specificity corresponding to the optimal critical values of IL-19 was 0.940 and 0.580,VASH-1 was 0.660 and 0.830,and NLR was 0.920 and 0.630,respectively.The combined sensitivity and specificity of the three methods was 0.860 and 0.880.Conclusion The serum IL-19,VASH-1,and NLR of T2DN patients are increased,and the combination of serum IL-19,VASH-1,and NLR has high predictive value for T2DN.

关 键 词：2型糖尿病肾病 白介素19 血管生成抑制蛋白1 中性粒细胞与淋巴细胞比值 诊断价值 

分 类 号：R587.2[医药卫生—内分泌]