血清IgA、IgG、IgM及Hcy、血脂与突发性聋患者病情程度的关系  

Relationship Between Serum IgA,IgG,IgM,Hcy,Blood Lipids and the Severity of Sudden Deafness in Patients

作　　者：李伟亚 王军 庞海龙 LI Weiya;WANG Jun;PANG Hailong(Department of Otolaryngology Head and Neck Surgery,General Hospital of Pingmei Shenma Medical Group,Pingdingshan 467000,China;Department of Clinical Laboratory,General Hospital of Pingmei Shenma Medical Group,Pingdingshan 467000,China)

机构地区：[1]平煤神马医疗集团总医院耳鼻咽喉头颈外科,河南平顶山467000 [2]平煤神马医疗集团总医院检验科,河南平顶山467000

出　　处：《河南医学研究》2024年第17期3195-3198,共4页Henan Medical Research

摘　　要：目的分析血清免疫球蛋白、同型半胱氨酸(Hcy)、血脂与突发性聋患者病情程度的关系。方法选取平煤神马集团总医院耳鼻喉科收治的100例突发性聋患者(病例组)及健康者100例(健康对照组)作为研究对象,采集两组血清样本后检测受检者血清免疫球蛋白(Ig)A、IgG、IgM、Hcy、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C),并将病例组按严重程度分为轻度、中度、重度及极重度,分析不同组别患者各指标水平,分析各指标与病情严重程度的相关性。结果病例组的血清IgA、IgG、IgM水平均较健康对照组降低,Hcy、TC、TG、LDL-C水平均高于健康对照组,HDL-C水平低于健康对照组(P<0.05)。病例组100例经病情程度分级,轻度组18例,中度组28例,重度组34例,极重度组20例,随着病情程度的增加,患者血清IgA、IgG、IgM水平越低,患者血清Hcy水平越高,HDL-C水平越低(P<0.05),但不同病情程度下患者的TC、TG、LDL-C水平差异无统计学意义(P>0.05)。采用Pearson相关分析显示,血清IgA、IgG、IgM、HDL-C水平与病情严重程度呈负相关性,Hcy水平与病情严重程度呈正相关性(P<0.05);TC、TG、LDL-C水平与病情程度无相关性(P>0.05)。结论突发性聋患者血清IgA、IgG、IgM水平降低,Hcy、TC、TG、LDL-C水平升高,HDL-C水平降低,且其水平与病情严重程度密切相关,可为临床诊治提供依据。Objective To analyze the role of serum immunoglobulin,homocysteine(Hcy),and blood lipids in evaluating the severity of sudden deafness in patients.Methods A total of 100 patients(case group)with sudden deafness admitted to the Otolaryngology Department of the General Hospital of Pingmei Shenma Medical Group and 100 healthy individuals(healthy control group)were selected.Two sets of serum samples were collected and tested for immunoglobulin(Ig)A,IgG,IgM,Hcy,total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C).The case group was divided into mild,moderate,and severe and extremely severe,the levels of various indicators in different groups of patients were analyzed,and the correlation between each indicator and the severity of the condition was analyzed.Results The serum levels of IgA,IgG,and IgM in the case group were lower than those in the healthy control group.The levels of Hcy,TC,TG,and LDL-C were higher than those in the healthy control group,while the level of HDL-C was lower than that in the healthy control group(P<0.05).A total of 100 cases in the case group were classified according to the severity of the disease.There were 18 cases in the mild group,28 cases in the moderate group,34 cases in the severe group,and 20 cases in the extremely severe group.As the severity of the disease increased,the serum levels of IgA,IgG,and IgM were lower,while the serum levels of Hcy and HDL-C were higher(P<0.05).However,there was no difference in the levels of TC,TG,and LDL-C among patients with different degrees of disease(P>0.05).Pearson correlation analysis showed that serum IgA,IgG,IgM,HDL-C levels were negatively correlated with the severity of the disease,while Hcy levels were positively correlated with the severity of the disease(P<0.05).There was no correlation between the levels of TC,TG,LDL-C and the severity of the disease(P>0.05).Conclusion In patients with sudden deafness,serum IgA,IgG,IgM levels decrease,while Hcy,TC,TG,LDL-C levels in

关 键 词：免疫球蛋白 同型半胱氨酸 血脂 突发性聋 病情程度 

分 类 号：R764[医药卫生—耳鼻咽喉科]