寿胎丸加减联合地屈孕酮对早期复发性流产患者血栓前状态的影响  

Effect of Modified Shoutai Pills Combined with Dydrogesterone on Prothrombotic State in Patients with Early Recurrent Abortion

作　　者：栗晓艳 叶希文 屈明霞 LI Xiaoyan;YE Xiwen;QU Mingxia(Department of Obstetrics and Gynecology,TCM Hospital of Xinyang,Xinyang 464000,China)

机构地区：[1]信阳市中医院妇产科,河南信阳464000

出　　处：《河南医学研究》2024年第17期3232-3235,共4页Henan Medical Research

摘　　要：目的探讨地屈孕酮、寿胎丸联合应用于早期复发性流产(RSA)患者中对血栓前状态的作用效果。方法前瞻性队列,选取信阳市中医院妇产科2020年10月至2022年6月早期RSA患者为研究对象,随机数字表法分为观察组(42例)、对照组(42例),对照组接受地屈孕酮治疗,观察组在对照组基础上联合寿胎丸加减治疗,治疗至孕12周。治疗前、孕12周时,评估并比较两组中医证候评分,检测并比较两组血栓前状态[D-二聚体、凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、纤维蛋白原(Fib)]、孕酮、β-人绒毛膜促性腺激素(β-HCG)。治疗期间记录两组不良反应发生情况及孕12周时妊娠情况。结果孕12周时,观察组中医证候评分、D-二聚体、Fib水平低于对照组,PT、孕酮、APTT、β-HCG水平均高于对照组(P<0.05);两组治疗期间不良反应发生率比较,差异无统计学意义(P>0.05);相较于对照组,观察组早期妊娠成功率更高(P<0.05)。结论将地屈孕酮、寿胎丸联合应用于早期RSA女性中,可帮助临床症状缓解,促使血栓前状态、β-HCG及孕酮情况改善,进而增加早期妊娠成功率,且两药联合应用不会增加不良反应。Objective To investigate the effect of dydrogesterone combined with Shoutai Pills on the prethrombotic state in patients with recurrent spontaneous abortion(RSA).Methods In the prospective cohort,patients with early RSA in the Department of Obstetrics and Gynecology of TCM Hospital of Xinyang from October 2020 to June 2022 were selected as the research objects.They were divided into observation group(42 cases)and control group(42 cases)by random number table method.The control group was treated with dydrogesterone,and the observation group was treated with Shoutai Pills on the basis of the control group.The treatment lasted until 12 weeks of pregnancy.Before treatment and at 12 weeks of pregnancy,the traditional Chinese medicine symptom scores of the two groups were evaluated and compared.The prothrombotic state indexes[D-dimer,prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(Fib)],progesterone andβ-human chorionic gonadotropin(β-HCG)were detected and compared between the two groups.The occurrence of adverse reactions and pregnancy at 12 weeks of gestation were recorded in both groups during treatment.Results At 12 weeks of pregnancy,the traditional Chinese medicine syndrome score,D-dimer and Fib levels in the observation group were lower than those in the control group,and the levels of PT,progesterone,APTT andβ-HCG were higher than those in the control group(P<0.05).There was no difference in the incidence of adverse reactions during treatment between the two groups(P>0.05).Compared with the control group,the success rate of early pregnancy in the observation group was higher(P<0.05).Conclusion The combined application of dydrogesterone and Shoutai Pills in women with early RSA can help relieve clinical symptoms,promote the improvement of prethrombotic state,β-HCG and progesterone,and then increase the success rate of early pregnancy,and the combined application of the two drugs will not increase adverse reactions.

关 键 词：早期复发性流产 寿胎丸 地屈孕酮 血栓前状态 妊娠 

分 类 号：R714.21[医药卫生—妇产科学]