窦房结节律调控的动力学机制综述  

A review on the dynamical mechanisms of rhythmic regulation of sinoatrial node

作　　者：黄晓东 汪瑞 Huang Xiaodong;Wang Rui(School of Physics and Optoeletronics,South China University of Technology,Guangzhou 510641,China)

机构地区：[1]华南理工大学物理与光电学院,广州510641

出　　处：《河南师范大学学报（自然科学版）》2024年第6期97-106,共10页Journal of Henan Normal University(Natural Science Edition)

基　　金：国家自然科学基金(11205062);广东省自然科学基金(2021A1515010500)。

摘　　要：窦房结是包埋在右心房的一小片可以自发电位振荡的组织,是整个心脏搏动的发起点.其节律失常会诱发一系列的综合征.窦房结节律的发起和调控,是心脏电生理和医学在窦房结研究领域的关注点.随着近几十年来非线性动力学被引入心律失常领域,心脏疾病与物理学的结合研究为这一医学范畴的问题带来了重要的理论发展.旨在综述从非线性动力学的角度研究窦房结节律所取得的一些重要成果,比较详细地介绍窦房结数值模型、节律调控的分岔机制、信号传导条件、心率变异等方面的研究进展.从目前的发展趋势来看,非线性动力学有可能成为一个有效解释窦房结节律调控的理论框架,因此,建议在多尺度建模和基于多尺度模型进行基础动力学理论分析方面做进一步的研究工作.Sinoatrial node(SAN)is a piece of tissue embedded in the right atrium,which is the pacemaker of the whole heart.The abnormal rhythm of SAN may cause diverse arrhythmias.The central focus of SAN in physiology and medicine are the pacemaking initiation and regulation.As nonlinear dynamics was introduced into the research of arrhythmias,in the past few decades the interdisciplinary subject of cardiovascular physics has brought about great progresses for such medical problems.The aim of the present paper is to review the relevant advances of SAN rhythm regulation obtained by nonlinear dynamics,in which the numerical modeling of SAN,the bifurcation mechanisms of heart rate regulation,the conditions of signal propagation,and heart rate variability are discussed.From the developmental trend,we find that nonlinear dynamics may become an effective theoretical framework for SAN.Therefore,we suggest further investigations in multi-scale modeling and the associated dynamical theories in the future.

关 键 词：生物物理 非线性动力学 窦房结 数值模拟 

分 类 号：O415[理学—理论物理]