联合有限元法和蒙特卡罗模拟的颅骨对光热影响  

Effect of skull on photothermal effect based on Monte Carlo method and finite element method

作　　者：宋贤林 游博康 李思行 Song Xianlin;You Bokang;Li Sihang(School of Information Engineering,Nanchang University,Nanchang 330031,China;Jiluan Academy,Nanchang University,Nanchang 330031,China)

机构地区：[1]南昌大学信息工程学院,南昌330031 [2]南昌大学际銮书院,南昌330031

出　　处：《河南师范大学学报（自然科学版）》2024年第6期107-112,I0003,I0004,共8页Journal of Henan Normal University(Natural Science Edition)

基　　金：国家自然科学基金(62265011);江西省自然科学基金(20224BAB212006,20232BAB202038)。

摘　　要：利用MCmatlab程序构建了小鼠在有颅骨和无颅骨情况下的脑部光热模型,联合蒙特卡罗方法和有限元法来研究颅骨对脑部光热效应的影响.利用蒙特卡罗方法模拟大量光子在不同脑组织中的传播规律;利用有限元法计算每个单元对光能量的吸收,进而获得脑组织的温度分布.仿真结果表明:在有颅骨的情况下,光在穿过头皮和颅骨时会发生严重的吸收和散射,只有小部分光子能够穿过头皮和颅骨被血管和灰质吸收,光热效应较弱;在无颅骨的情况下,绝大多数的光能够入射到灰质中,血管能够吸收大部分的能量而导致温度上升显著,血管温度上升约0.2℃,光热效应明显.In this study,MCmatlab was used to construct a photothermal model of mouse brain with and without skull,and the effect of skull on brain photothermal effect was studied by Monte Carlo method and finite element method.Monte Carlo method can be used to simulate the propagation of a large number of photons in different brain tissues.Then the finite element method is used to calculate the absorption of light energy by each unit,and the temperature distribution of brain tissue is obtained.The simulation results show that in the case of skull,the light will be absorbed and scattered seriously through the scalp and skull.Only a small part of the photons can be absorbed by blood vessels and gray matter through the scalp and skull,and the photothermal effect is very weak.In the absence of skull,most of the light can enter the gray matter,and the blood vessels can absorb most of the energy,resulting in a significant increase in temperature.Compared with the temperature rise on the blood vessels with skull,the temperature rise on the blood vessels without skull increases by 0.2℃,and the photothermal effect is obvious.

关 键 词：蒙特卡罗方法 有限元法 颅骨 光热效应 脑成像 

分 类 号：Q63[生物学—生物物理学]